Yasushi Tsujimoto1, Hiraku Tsujimoto2, Yuki Kataoka1, Miho Kimachi1, Sayaka Shimizu1, Tatsuyoshi Ikenoue1, Shingo Fukuma1, Yosuke Yamamoto3, Shunichi Fukuhara1. 1. Department of Healthcare Epidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. 2. Hospital Care Research Unit, Hyogo Prefectural Amagasaki General Medical Center, Higashi-Naniwa-Cho 2-17-77, Amagasaki, Hyogo 660-8550, Japan. 3. Department of Healthcare Epidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: yamamoto.yosuke.5n@kyoto-u.ac.jp.
Abstract
OBJECTIVES: To describe the registration of systematic review (SR) protocols and examine whether or not registration reduced the outcome reporting bias in high-impact journals. STUDY DESIGN AND SETTING: We searched MEDLINE via PubMed to identify SRs of randomized controlled trials of interventions. We included SRs published between August 2009 and June 2015 in the 10 general and internal medicinal journals with the highest impact factors in 2013. We examined the proportion of SR protocol registration and investigated the relationship between registration and outcome reporting bias using multivariable logistic regression. RESULTS: Among the 284 included reviews, 60 (21%) protocols were registered. The proportion of registration increased from 5.6% in 2009 to 27% in 2015 (P for trend <0.001). Protocol registration was not associated with outcome reporting bias (adjusted odds ratio [OR] 0.85, 95% confidence interval [CI] 0.39-1.86). The association between Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) adherence and protocol registration was not statistically significant (OR 1.09, 95% CI 0.59-2.01). CONCLUSIONS: Six years after the launch of the PRISMA statement, the proportion of protocol registration in high-impact journals has increased some but remains low. The present study found no evidence suggesting that protocol registration reduced outcome reporting bias.
OBJECTIVES: To describe the registration of systematic review (SR) protocols and examine whether or not registration reduced the outcome reporting bias in high-impact journals. STUDY DESIGN AND SETTING: We searched MEDLINE via PubMed to identify SRs of randomized controlled trials of interventions. We included SRs published between August 2009 and June 2015 in the 10 general and internal medicinal journals with the highest impact factors in 2013. We examined the proportion of SR protocol registration and investigated the relationship between registration and outcome reporting bias using multivariable logistic regression. RESULTS: Among the 284 included reviews, 60 (21%) protocols were registered. The proportion of registration increased from 5.6% in 2009 to 27% in 2015 (P for trend <0.001). Protocol registration was not associated with outcome reporting bias (adjusted odds ratio [OR] 0.85, 95% confidence interval [CI] 0.39-1.86). The association between Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) adherence and protocol registration was not statistically significant (OR 1.09, 95% CI 0.59-2.01). CONCLUSIONS: Six years after the launch of the PRISMA statement, the proportion of protocol registration in high-impact journals has increased some but remains low. The present study found no evidence suggesting that protocol registration reduced outcome reporting bias.
Authors: Wilson W S Tam; Kenneth K H Lo; Parames Khalechelvam; Joey Seah; Shawn Y S Goh Journal: BMC Med Res Methodol Date: 2017-11-25 Impact factor: 4.615
Authors: Juan Ruano; Francisco Gómez-García; Jesús Gay-Mimbrera; Macarena Aguilar-Luque; José Luis Fernández-Rueda; Jesús Fernández-Chaichio; Patricia Alcalde-Mellado; Pedro J Carmona-Fernandez; Juan Luis Sanz-Cabanillas; Isabel Viguera-Guerra; Francisco Franco-García; Manuel Cárdenas-Aranzana; José Luis Hernández Romero; Marcelino Gonzalez-Padilla; Beatriz Isla-Tejera; Antonio Velez Garcia-Nieto Journal: Syst Rev Date: 2018-03-09