Literature DB >> 28242275

Recent developments in drug discovery against the protozoal parasites Cryptosporidium and Toxoplasma.

Prinessa Chellan1, Peter J Sadler1, Kirkwood M Land2.   

Abstract

Apicomplexan parasites cause some of the most devastating human diseases, including malaria, toxoplasmosis, and cryptosporidiosis. New drug discovery is imperative in light of increased resistance. In this digest article, we briefly explore some of the recent and promising developments in new drug discovery against two apicomplexan parasites, Cryptosporidium and Toxoplasma.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28242275     DOI： 10.1016/j.bmcl.2017.01.046

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.

Authors:  Tamila Galaka; Bruno N Falcone; Catherine Li; Sergio H Szajnman; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Journal:  Bioorg Med Chem       Date:  2019-07-04       Impact factor: 3.641

2.  Identification of adaptive inhibitors of Cryptosporidium parvum fatty acyl-coenzyme A synthetase isoforms by virtual screening.

Authors:  Somdeb Chattopadhyay; Rajani Kanta Mahapatra
Journal:  Parasitol Res       Date:  2019-09-05       Impact factor: 2.289

Review 3.  Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis.

Authors:  John G M Mina; P W Denny
Journal:  Parasitology       Date:  2017-06-22       Impact factor: 3.234

4.  Protective Effect Against Toxoplasmosis in BALB/c Mice Vaccinated With Recombinant Toxoplasma gondii MIF, CDPK3, and 14-3-3 Protein Cocktail Vaccine.

Authors:  Fang Liu; Minmin Wu; Jie Wang; Hongyang Wen; Ran An; Haijian Cai; Li Yu; Jilong Shen; Lijian Chen; Jian Du
Journal:  Front Immunol       Date:  2021-12-22       Impact factor: 7.561

5.  Immune responses and protection after DNA vaccination against Toxoplasma gondii calcium-dependent protein kinase 2 (TgCDPK2).

Authors:  Kai Chen; Jin-Lei Wang; Si-Yang Huang; Wen-Bin Yang; Wei-Ning Zhu; Xing-Quan Zhu
Journal:  Parasite       Date:  2017-11-09       Impact factor: 3.000

6.  Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity.

Authors:  C Loeuillet; B Touquet; B Oury; N Eddaikra; J L Pons; J F Guichou; G Labesse; D Sereno
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-01-31       Impact factor: 4.077

7.  Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.

Authors:  Yogavel Manickam; Nipun Malhotra; Siddhartha Mishra; Palak Babbar; Abhishek Dusane; Benoît Laleu; Valeria Bellini; Mohamed-Ali Hakimi; Alexandre Bougdour; Amit Sharma
Journal:  PLoS Pathog       Date:  2022-03-25       Impact factor: 6.823
  7 in total

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