Christina M Parrinello1, Simin Hua2, Mercedes R Carnethon3, Linda C Gallo4, Barry I Hudson5, Ronald B Goldberg5, Alan M Delamater6, Robert C Kaplan2, Carmen R Isasi2. 1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: christina.parrinello@einstein.yu.edu. 2. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. 3. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 4. Department of Psychology, San Diego State University, San Diego, CA, USA. 5. Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA. 6. Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Abstract
AIMS: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. METHODS: Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02ng/mL, respectively). RESULTS: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p<0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). CONCLUSIONS: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.
AIMS: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. METHODS: Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02ng/mL, respectively). RESULTS: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p<0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). CONCLUSIONS:Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.
Authors: Etto C Eringa; Erik H Serne; Rick I Meijer; Casper G Schalkwijk; Alfons J H M Houben; Coen D A Stehouwer; Yvo M Smulders; Victor W M van Hinsbergh Journal: Rev Endocr Metab Disord Date: 2013-03 Impact factor: 6.514
Authors: Paul D Sorlie; Larissa M Avilés-Santa; Sylvia Wassertheil-Smoller; Robert C Kaplan; Martha L Daviglus; Aida L Giachello; Neil Schneiderman; Leopoldo Raij; Gregory Talavera; Matthew Allison; Lisa Lavange; Lloyd E Chambless; Gerardo Heiss Journal: Ann Epidemiol Date: 2010-08 Impact factor: 3.797
Authors: Selena T Nguyen-Rodriguez; Linda C Gallo; Carmen R Isasi; Orfeu M Buxton; KaMala S Thomas; Daniela Sotres-Alvarez; Susan Redline; Sheila F Castañeda; Mercedes R Carnethon; Martha L Daviglus; Krista M Perreira Journal: Ann Behav Med Date: 2020-06-12