Marta Załęska-Kocięcka1, Paweł Jezierski2, Maciej Grabowski3, Krzysztof Kuśmierski4, Maciej Dąbrowski5, Katarzyna Piotrowska6, Marek Banaszewski1, Jacek Imiela7, Janina Stępińska1. 1. Cardiac Intensive Therapy Clinic, Institute of Cardiology, Warsaw, Poland. 2. Neurology Clinic, Institute of Psychiatry & Neurology, Warsaw, Poland. 3. Acquired Valve Disease Clinic, Institute of Cardiology, Warsaw, Poland. 4. Cardiac Surgery & Transplantology Clinic, Institute of Cardiology, Warsaw, Poland. 5. Interventional Cardiology & Angiology Clinic, Institute of Cardiology, Warsaw, Poland. 6. Department of Quantitative Methods & Information Technology, Kozminski University, Warsaw, Poland. 7. Department of Internal Medicine & Nephrology, Miedzyleski Hospital, Warsaw, Poland.
Abstract
AIM: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice. MATERIALS & METHODS: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months. RESULTS: Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0.005). Patients with β2M increase over the median change also failed to improve a delayed-word-recall domain of the test (p = 0.826) while patients with a lower increase improved results in the domain (p = 0.004). After 6 months, MMSE improvement was associated with a significant decrease in β2M (p = 0.042). CONCLUSION: These are the first in man data demonstrating relation between changes in cognition and β2M. The phenomenon was reversible which indicates its therapeutic potential.
AIM: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice. MATERIALS & METHODS: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months. RESULTS:Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0.005). Patients with β2M increase over the median change also failed to improve a delayed-word-recall domain of the test (p = 0.826) while patients with a lower increase improved results in the domain (p = 0.004). After 6 months, MMSE improvement was associated with a significant decrease in β2M (p = 0.042). CONCLUSION: These are the first in man data demonstrating relation between changes in cognition and β2M. The phenomenon was reversible which indicates its therapeutic potential.
Authors: Johannes B Scheppach; Josef Coresh; Aozhou Wu; Rebecca F Gottesman; Thomas H Mosley; David S Knopman; Morgan E Grams; A Richey Sharrett; Silvia Koton Journal: Am J Kidney Dis Date: 2020-05-16 Impact factor: 8.860