| Literature DB >> 2823980 |
Abstract
Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to release endogenous CRF.Entities:
Mesh:
Substances:
Year: 1987 PMID: 2823980 DOI: 10.1016/0006-8993(87)90953-x
Source DB: PubMed Journal: Brain Res ISSN: 0006-8993 Impact factor: 3.252