Sara G Aguilar-Navarro1, Alberto J Mimenza-Alvarado1, José Alberto Ávila-Funes1, Teresa Juárez-Cedillo2, Carolina Bernal-López1, Celia G Hernández-Favela3. 1. Geriatrics Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. 2. Epidemiology and Health Services Research Unit, Area of Aging, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social and Faculty of Superior Studies (FES) Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico. 3. Universidad Autónoma de Coahuila, School of Medicine, Torreón Unit, Torreón Coahuila, Mexico.
Abstract
BACKGROUND: Mild cognitive impairment (MCI) is considered a clinical stage between normal cognitive aging and dementia. The clinical course of MCI is heterogeneous, with a significant number of cases progressing to dementia or reverting back to normal. OBJECTIVE: To determine the predictors of conversion from mild cognitive impairment to dementia among Mexican older adults. MATERIALS AND METHODS: A sample of 175 persons underwent clinical and neuropsychological evaluation to establish mild cognitive impairment diagnosis. These patients were followed-up for a mean 3.5 years. RESULTS: Mean age was 81.7 (± 6.9) years, 57% were women, and mean education level was 9.5 (± 6.1) years. Sixty-one percent of mild cognitive impairment participants progressed to dementia. Multivariate Cox regression analysis showed that progression to dementia was associated with age (HR: 4.95; 95% CI: 1.96-12.46; p = 0.001), low education level (HR: 5.81; 95% CI: 1.90-7.78; p < 0.002), history of stroke (HR: 3.92; 95% CI: 1.37-11.16; p < 0.012) and cognitive decline (HR: 1.31; 95% CI: 1.18-1.45; p = 0.000). CONCLUSIONS: Age, poor education, cognitive decline, and a history of stroke were predictors of conversion to dementia. The identification and control of modifiable risk factors could influence conversion to dementia.
BACKGROUND: Mild cognitive impairment (MCI) is considered a clinical stage between normal cognitive aging and dementia. The clinical course of MCI is heterogeneous, with a significant number of cases progressing to dementia or reverting back to normal. OBJECTIVE: To determine the predictors of conversion from mild cognitive impairment to dementia among Mexican older adults. MATERIALS AND METHODS: A sample of 175 persons underwent clinical and neuropsychological evaluation to establish mild cognitive impairment diagnosis. These patients were followed-up for a mean 3.5 years. RESULTS: Mean age was 81.7 (± 6.9) years, 57% were women, and mean education level was 9.5 (± 6.1) years. Sixty-one percent of mild cognitive impairmentparticipants progressed to dementia. Multivariate Cox regression analysis showed that progression to dementia was associated with age (HR: 4.95; 95% CI: 1.96-12.46; p = 0.001), low education level (HR: 5.81; 95% CI: 1.90-7.78; p < 0.002), history of stroke (HR: 3.92; 95% CI: 1.37-11.16; p < 0.012) and cognitive decline (HR: 1.31; 95% CI: 1.18-1.45; p = 0.000). CONCLUSIONS: Age, poor education, cognitive decline, and a history of stroke were predictors of conversion to dementia. The identification and control of modifiable risk factors could influence conversion to dementia.
Authors: Elżbieta Kuźma; Ilianna Lourida; Sarah F Moore; Deborah A Levine; Obioha C Ukoumunne; David J Llewellyn Journal: Alzheimers Dement Date: 2018-08-31 Impact factor: 21.566
Authors: Sara G Aguilar-Navarro; Itzel I Gonzalez-Aparicio; José Alberto Avila-Funes; Teresa Juárez-Cedillo; Teresa Tusié-Luna; Alberto Jose Mimenza-Alvarado Journal: Brain Sci Date: 2021-01-07