P D Griffiths1, M Bradburn2, M J Campbell2, D J A Connolly3, C L Cooper2, D Jarvis4, M D Kilby5, G Mason6, C Mooney7, S C Robson8, A Wailoo9. 1. Academic Unit of Radiology, University of Sheffield, Glossop Road, Sheffield, S10 2JF, UK; INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield S10 2JF, UK. 2. Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK. 3. Department of Radiology, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, UK; Royal Hallamshire Hospital, Sheffield Teaching Hospital, Glossop Road, Sheffield S10 2JF, UK. 4. Academic Unit of Radiology, University of Sheffield, Glossop Road, Sheffield S10 2JF, UK. 5. Centre for Women's & Newborn Health, Institute of Metabolism & Systems Research, University of Birmingham, Birmingham B15 2TT, UK; Fetal Medicine Centre, Birmingham Women's Foundation Trust (Birmingham Health Partners), Birmingham, B15 2TG, UK. 6. Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK. 7. Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK. Electronic address: c.d.mooney@sheffield.ac.uk. 8. Newcastle University, Newcastle upon Tyne NE2 4HH, UK. 9. Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK.
Abstract
AIM: To measure possible change in diagnostic confidence by performing in utero magnetic resonance imaging (iuMRI) studies on fetuses with brain abnormalities recognised on ultrasonography (US). MATERIALS AND METHODS: The analyses are based on the primary cohort from the prospective MERIDIAN study, which consisted of 570 fetuses with brain abnormalities detected on US, with iuMRI performed within 2 weeks of US and complete outcome reference data. The cohort was recruited between July 2011 and August 2014, and written informed consent was obtained for all participants. They all had indicators of diagnostic confidence measured on US by fetal medicine experts and iuMRI by the reporting radiologists. Three assessments were carried out using the conventional uncorrected (C2-C1%) method, the conventional (C2-C1%) with the Omary correction, and the score-based weighted average method. RESULTS: All three assessments showed statistically significant (p<0·0001) positive effects indicating that iuMRI was potentially beneficial when included in the diagnostic pathway for prenatal structural brain anomalies (in terms of diagnostic confidence). CONCLUSION: These results strongly support the routine clinical use of iuMRI as an adjunct to US when assessing fetuses with structural brain abnormalities. Crown
AIM: To measure possible change in diagnostic confidence by performing in utero magnetic resonance imaging (iuMRI) studies on fetuses with brain abnormalities recognised on ultrasonography (US). MATERIALS AND METHODS: The analyses are based on the primary cohort from the prospective MERIDIAN study, which consisted of 570 fetuses with brain abnormalities detected on US, with iuMRI performed within 2 weeks of US and complete outcome reference data. The cohort was recruited between July 2011 and August 2014, and written informed consent was obtained for all participants. They all had indicators of diagnostic confidence measured on US by fetal medicine experts and iuMRI by the reporting radiologists. Three assessments were carried out using the conventional uncorrected (C2-C1%) method, the conventional (C2-C1%) with the Omary correction, and the score-based weighted average method. RESULTS: All three assessments showed statistically significant (p<0·0001) positive effects indicating that iuMRI was potentially beneficial when included in the diagnostic pathway for prenatal structural brain anomalies (in terms of diagnostic confidence). CONCLUSION: These results strongly support the routine clinical use of iuMRI as an adjunct to US when assessing fetuses with structural brain abnormalities. Crown
Authors: Ruth Batty; Mary L Gawne-Cain; Cara Mooney; Laura Mandefield; Michael Bradburn; Gerald Mason; Paul D Griffiths Journal: Eur Radiol Date: 2018-06-15 Impact factor: 5.315
Authors: Anthony R Hart; Nicholas D Embleton; Michael Bradburn; Daniel J A Connolly; Laura Mandefield; Cara Mooney; Paul D Griffiths Journal: Lancet Child Adolesc Health Date: 2019-11-27