Literature DB >> 28237880

Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood.

Hui-Xia Huo1, Yu-Fan Gu1, Hui Sun1, Yun-Feng Zhang1, Wen-Jing Liu1, Zhi-Xiang Zhu1, She-Po Shi1, Yue-Lin Song1, Hong-Wei Jin2, Yun-Fang Zhao3, Peng-Fei Tu1, Jun Li4.   

Abstract

Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2-4 were determined by electronic circular dichroism (ECD) calculations. Compounds 2-4, 11, 12, and 15 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with IC50 values in the range 1.6-7.3μM.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  2-(2-phenylethyl)chromone; Anti-inflammatory activity; Aquilaria sinensis; Chinese agarwood; Electronic circular dichroism

Mesh：

Substances：

Year:  2017        PMID： 28237880     DOI： 10.1016/j.fitote.2017.02.009

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  11 in total

1.  Phytochemical Constituents of Aquilaria malaccensis Leaf Extract and Their Anti-Inflammatory Activity against LPS/IFN-γ-Stimulated RAW 264.7 Cell Line.

Authors:  Manar A Eissa; Yumi Z H-Y Hashim; Saripah S S Abdul Azziz; Hamzah Mohd Salleh; Muhammad Lokman Md Isa; Nor Malia Abd Warif; Fauziah Abdullah; Eman Ramadan; Dina M El-Kersh
Journal:  ACS Omega       Date:  2022-04-26

2.  GC-MS Study of the Chemical Components of Different Aquilaria sinensis (Lour.) Gilgorgans and Agarwood from Different Asian Countries.

Authors:  Meng-Ru Wang; Wei Li; Sha Luo; Xin Zhao; Chun-Hui Ma; Shou-Xin Liu
Journal:  Molecules       Date:  2018-08-28       Impact factor: 4.411

3.  Inhalation Administration of Agarwood Incense Rescues Scopolamine-Induced Learning and Memory Impairment in Mice.

Authors:  Muxuan Han; Hao Zhang; Minghui Hu; Wei Sun; Zifa Li; Guimao Cao; Xiwen Geng; Sheng Wei
Journal:  Front Pharmacol       Date:  2021-12-24       Impact factor: 5.810

4.  Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.

Authors:  Xiao-Hui Wang; Bo-Wen Gao; Yu Nakashima; Takahiro Mori; Zhong-Xiu Zhang; Takeshi Kodama; Yuan-E Lee; Ze-Kun Zhang; Chin-Piow Wong; Qian-Qian Liu; Bo-Wen Qi; Juan Wang; Jun Li; Xiao Liu; Ikuro Abe; Hiroyuki Morita; Peng-Fei Tu; She-Po Shi
Journal:  Nat Commun       Date:  2022-01-17       Impact factor: 14.919

5.  Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation.

Authors:  Canhong Wang; Deqian Peng; Yangyang Liu; Yulan Wu; Peng Guo; Jianhe Wei
Journal:  Evid Based Complement Alternat Med       Date:  2021-09-18       Impact factor: 2.629

6.  Effects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis.

Authors:  Ningnan Zhang; Shiyu Xue; Jie Song; Xiuren Zhou; Dahao Zhou; Xiaojin Liu; Zhou Hong; Daping Xu
Journal:  BMC Plant Biol       Date:  2021-12-13       Impact factor: 4.215

Review 7.  Overview of sesquiterpenes and chromones of agarwood originating from four main species of the genus Aquilaria.

Authors:  Mei Gao; Xiaomin Han; Ying Sun; Hongjiang Chen; Yun Yang; Yangyang Liu; Hui Meng; Zhihui Gao; Yanhong Xu; Zheng Zhang; Jianping Han
Journal:  RSC Adv       Date:  2019-01-30       Impact factor: 4.036

Review 8.  Chemical Constituents and Pharmacological Activity of Agarwood and Aquilaria Plants.

Authors:  Shuai Wang; Zhangxin Yu; Canhong Wang; Chongming Wu; Peng Guo; Jianhe Wei
Journal:  Molecules       Date:  2018-02-07       Impact factor: 4.411

9.  4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production by suppressing the NF-κB and MAPK signaling pathways.

Authors:  Jing Fu; Zuping Zeng; Lu Zhang; Yan Wang; Ping Li
Journal:  Braz J Med Biol Res       Date:  2020-10-30       Impact factor: 2.590

10.  Discovery of Biomarkers and Potential Mechanisms of Agarwood Incense Smoke Intervention by Untargeted Metabolomics and Network Pharmacology.

Authors:  Meiyue Dong; Haitao Du; Xueling Li; Ling Zhang; Xiaoming Wang; Zhenguo Wang; Haiqiang Jiang
Journal:  Drug Des Devel Ther       Date:  2022-01-26       Impact factor: 4.162
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