OBJECTIVE: To characterize viral co-infections among representative hospitalized measles cases during the 2014 Hanoi outbreak. METHODS: Throat swabs were collected from 54 pediatric patients with confirmed measles, and molecular diagnostics performed for 10 additional viral respiratory pathogens (Influenza A/H1N1pdm09; A/H3N2 and influenza B; Parainfluenza 1, 2, 3; Respiratory Synctial Virus, RSV; human Metapneumovirus, hMPV; Adenovirus and Picornavirus). RESULTS: Twenty-one cases (38.9%) showed evidence of infection with other respiratory viruses: 15 samples contained measles plus one additional virus, and 6 samples contained measles plus 2 additional viruses. Adenovirus was detected as a predominant cause of co-infections (13 cases; 24.1%), followed by RSV (6 cases; 11.1%), A/H1N1pdm09 (3 cases; 5.6%), PIV3 (3 cases; 3.7%), Rhinovirus (3 cases; 3.7%) and hMPV (1 case; 1.96%). CONCLUSIONS: Viral co-infections identified from pediatric measles cases may have contributed to increased disease severity and high rate of fatal outcomes. Optimal treatment of measles cases may require control of multiple viral respiratory pathogens.
OBJECTIVE: To characterize viral co-infections among representative hospitalized measles cases during the 2014 Hanoi outbreak. METHODS: Throat swabs were collected from 54 pediatric patients with confirmed measles, and molecular diagnostics performed for 10 additional viral respiratory pathogens (Influenza A/H1N1pdm09; A/H3N2 and influenza B; Parainfluenza 1, 2, 3; Respiratory Synctial Virus, RSV; human Metapneumovirus, hMPV; Adenovirus and Picornavirus). RESULTS: Twenty-one cases (38.9%) showed evidence of infection with other respiratory viruses: 15 samples contained measles plus one additional virus, and 6 samples contained measles plus 2 additional viruses. Adenovirus was detected as a predominant cause of co-infections (13 cases; 24.1%), followed by RSV (6 cases; 11.1%), A/H1N1pdm09 (3 cases; 5.6%), PIV3 (3 cases; 3.7%), Rhinovirus (3 cases; 3.7%) and hMPV (1 case; 1.96%). CONCLUSIONS: Viral co-infections identified from pediatric measles cases may have contributed to increased disease severity and high rate of fatal outcomes. Optimal treatment of measles cases may require control of multiple viral respiratory pathogens.
Authors: Deshayne B Fell; Jeanene Johnson; Zohar Mor; Mark A Katz; Becky Skidmore; Kathleen M Neuzil; Justin R Ortiz; Niranjan Bhat Journal: BMJ Open Date: 2017-09-07 Impact factor: 2.692
Authors: Karen A Alroy; Trang Thuy Do; Phu Dac Tran; Tan Quang Dang; Long Ngoc Vu; Nga Thi Hang Le; Anh Duc Dang; Nghia Duy Ngu; Tu Huy Ngo; Phuong Vu Mai Hoang; Lan Trong Phan; Thuong Vu Nguyen; Long Thanh Nguyen; Thinh Viet Nguyen; Mai Quang Vien; Huy Xuan Le; Anh The Dao; Trieu Bao Nguyen; Duoc Tho Pham; Van Thi Tuyet Nguyen; Thanh Ngoc Pham; Binh Hai Phan; Brett Whitaker; Thuy Thi Thu Do; Phuong Anh Dao; S Arunmozhi Balajee; Anthony W Mounts Journal: Influenza Other Respir Viruses Date: 2018-06-10 Impact factor: 4.380
Authors: Caitlin D Bohannon; Zachary Ende; Weiping Cao; Wadzanai P Mboko; Priya Ranjan; Amrita Kumar; Margarita Mishina; Samuel Amoah; Shivaprakash Gangappa; Suresh K Mittal; Jonathan F Lovell; Adolfo García-Sastre; Blaine A Pfeifer; Bruce A Davidson; Paul Knight; Suryaprakash Sambhara Journal: Adv Sci (Weinh) Date: 2021-06-30 Impact factor: 16.806