| Literature DB >> 2823744 |
C P Karakousis1, P Dal Cin, C Turc-Carel, J Limon, A A Sandberg.
Abstract
A cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a non-characteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.Entities:
Mesh：
Year: 1987 PMID： 2823744 DOI： 10.1001/archsurg.1987.01400230043007
Source DB: PubMed Journal: Arch Surg ISSN： 0004-0010