Literature DB >> 28236591

Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities.

Xinzhou Yang1, Shihao Deng1, Mi Huang1, Jialin Wang1, Li Chen1, Mingrui Xiong1, Jie Yang1, Sijiang Zheng1, Xinhua Ma1, Ping Zhao2, Yunjiang Feng3.   

Abstract

Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
Copyright © 2017. Published by Elsevier Ltd.

Entities:  

Keywords:  Antidiabetic; Flavone; Flavonoids; GLUT-4; Polyprenylated flavonoids; Traditional Chinese Medicine

Mesh：

Substances：

Year:  2017        PMID： 28236591     DOI： 10.1016/j.bmcl.2017.01.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Biological Activities and Secondary Metabolites from Sophora tonkinensis and Its Endophytic Fungi.

Authors:  Jia-Jun Liang; Pan-Pan Zhang; Wei Zhang; Da Song; Xin Wei; Xin Yin; Yong-Qiang Zhou; Xiang Pu; Ying Zhou
Journal:  Molecules       Date:  2022-08-29       Impact factor: 4.927

2.  Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression.

Authors:  Pisey Pel; Hee-Sung Chae; Piseth Nhoek; Young-Mi Kim; Chae-Yeong An; Hunseung Yoo; Minseok Kang; Hyun Woo Kim; Young Hee Choi; Young-Won Chin
Journal:  ACS Omega       Date:  2022-06-08

3.  Antidiabetic effects of a lipophilic extract obtained from flowers of Wisteria sinensis by activating Akt/GLUT4 and Akt/GSK3β.

Authors:  Yibing Lv; Wenjie Ren; Yirui Zhang; Yun Huang; Ji Hao; Kun Ma; Yuanren Ma; Xinzhou Yang
Journal:  Food Nutr Res       Date:  2020-09-07       Impact factor: 3.894

4.  Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone.

Authors:  Yu Fen Zheng; Soo Hyeon Bae; Zhouchi Huang; Soon Uk Chae; Seong Jun Jo; Hyung Joon Shim; Chae Bin Lee; Doyun Kim; Hunseung Yoo; Soo Kyung Bae
Journal:  Pharmaceutics       Date:  2020-04-07       Impact factor: 6.321

5.  Preparative Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD.

Authors:  Mengyang Hou; Wenzhong Hu; Zhilong Xiu; Aili Jiang; Lei Men; Kexin Hao; Xingsheng Sun; Duo Cao
Journal:  Molecules       Date:  2019-09-03       Impact factor: 4.411

6.  Integrated transcriptome and small RNA sequencing analyses reveal a drought stress response network in Sophora tonkinensis.

Authors:  Ying Liang; Kunhua Wei; Fan Wei; Shuangshuang Qin; Chuanhua Deng; Yang Lin; Mingjie Li; Li Gu; Guili Wei; Jianhua Miao; Zhongyi Zhang
Journal:  BMC Plant Biol       Date:  2021-12-02       Impact factor: 4.215
  6 in total

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