BACKGROUND: The purpose of this study was to investigate the critical primary tumor depth of invasion in oral squamous cell carcinoma that would lead to a 20% or greater risk of nodal metastasis. METHODS: An institutional review board approved retrospective review of our head and neck database was performed from 2009 to 2014 and the data were statistically analyzed. RESULTS: Two hundred eighty-six patients with a diagnosis of oral squamous cell carcinoma who met our inclusion criteria underwent primary excision and neck dissection. For a depth of invasion of 1 mm or less, there were no patients with a positive node. From 1.1 mm to 2 mm of depth of invasion, there was 1 of 11 patients (9%) who had at least 1 positive node. At 2.1 mm to 3 mm, 5 of 25 patients (20%) had at least 1 positive node. CONCLUSION: Depth of invasion and the location of the tumor are 2 important variables to consider when making treatment recommendations to patients with clinical N0 disease.
BACKGROUND: The purpose of this study was to investigate the critical primary tumor depth of invasion in oral squamous cell carcinoma that would lead to a 20% or greater risk of nodal metastasis. METHODS: An institutional review board approved retrospective review of our head and neck database was performed from 2009 to 2014 and the data were statistically analyzed. RESULTS: Two hundred eighty-six patients with a diagnosis of oral squamous cell carcinoma who met our inclusion criteria underwent primary excision and neck dissection. For a depth of invasion of 1 mm or less, there were no patients with a positive node. From 1.1 mm to 2 mm of depth of invasion, there was 1 of 11 patients (9%) who had at least 1 positive node. At 2.1 mm to 3 mm, 5 of 25 patients (20%) had at least 1 positive node. CONCLUSION: Depth of invasion and the location of the tumor are 2 important variables to consider when making treatment recommendations to patients with clinical N0 disease.
Authors: Yassine Aaboubout; Quincy M van der Toom; Maria A J de Ridder; Maria J De Herdt; Berdine van der Steen; Cornelia G F van Lanschot; Elisa M Barroso; Maria R Nunes Soares; Ivo Ten Hove; Hetty Mast; Roeland W H Smits; Aniel Sewnaik; Dominiek A Monserez; Stijn Keereweer; Peter J Caspers; Robert J Baatenburg de Jong; Tom C Bakker Schut; Gerwin J Puppels; José A Hardillo; Senada Koljenović Journal: Front Oncol Date: 2021-03-12 Impact factor: 6.244
Authors: Maria J De Herdt; Berdine van der Steen; Quincy M van der Toom; Yassine Aaboubout; Stefan M Willems; Marjan H Wieringa; Robert J Baatenburg de Jong; Leendert H J Looijenga; Senada Koljenović; Jose A Hardillo Journal: Front Oncol Date: 2021-04-29 Impact factor: 6.244
Authors: Marta Filauro; Francesco Missale; Filippo Marchi; Andrea Iandelli; Andrea Luigi Camillo Carobbio; Francesco Mazzola; Giampiero Parrinello; Emanuele Barabino; Giuseppe Cittadini; Davide Farina; Cesare Piazza; Giorgio Peretti Journal: Eur Arch Otorhinolaryngol Date: 2020-10-21 Impact factor: 2.503
Authors: Inne J den Toom; Luuk M Janssen; Robert J J van Es; K Hakki Karagozoglu; Bart de Keizer; Stijn van Weert; Stefan M Willems; Elisabeth Bloemena; C René Leemans; Remco de Bree Journal: Head Neck Date: 2019-01-28 Impact factor: 3.147