Literature DB >> 28235985

[Spontaneous remission of HCV infection after autologous stem cell transplantation in a 58-year-old man].

L Reinhardt1,2, H Eiffert3, G Wulf4, P Ströbel5,6, S C B Bremer7,5, A Amanzada7, V Ellenrieder7,5, A Neesse7.   

Abstract

We report about a 58-year-old man with a chronic and treatment-naive hepatitis C virus (HCV) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. Subsequently, a high-level viremic reactivation of an occult hepatitis B virus (HBV) infection and also a reverse seroconversion was observed. Furthermore, a sustained spontaneous remission of HCV infection was seen. Antiviral therapy of HBV infection was initiated with tenofovir. Seven months after therapy initiation, the patient acquired an "anti-HBc-only" status. Antiviral therapy with tenofovir is still continued. The patient is in a good clinical condition.

Entities:  

Keywords:  Coinfection; Hepatitis B virus; Multiple myeloma; Seroconversion, reverse; Tenofovir

Mesh：

Substances：

Year:  2017        PMID： 28235985     DOI： 10.1007/s00108-017-0206-3

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN： 0020-9554            Impact factor:   0.743


  13 in total

1.  [Prophylaxis, diagnosis and therapy of hepatitis B virus infection - the German guideline].

Authors:  M Cornberg; U Protzer; J Petersen; H Wedemeyer; T Berg; W Jilg; A Erhardt; S Wirth; C Sarrazin; M M Dollinger; P Schirmacher; K Dathe; I B Kopp; S Zeuzem; W H Gerlich; M P Manns
Journal:  Z Gastroenterol       Date:  2011-07-11       Impact factor: 2.000

2.  Factors associated with spontaneous clearance of chronic hepatitis C virus infection.

Authors:  Naomi Bulteel; Prasanna Partha Sarathy; Ewan Forrest; Adrian J Stanley; Hamish Innes; Peter R Mills; Heather Valerio; Rory N Gunson; Celia Aitken; Jude Morris; Ray Fox; Stephen T Barclay
Journal:  J Hepatol       Date:  2016-05-04       Impact factor: 25.083

3.  Hepatitis A virus infection suppresses hepatitis C virus replication and may lead to clearance of HCV.

Authors:  Katja Deterding; Björn Tegtmeyer; Markus Cornberg; Johannes Hadem; Andrej Potthoff; Klaus H W Böker; Hans L Tillmann; Michael P Manns; Heiner Wedemeyer
Journal:  J Hepatol       Date:  2006-09-22       Impact factor: 25.083

4.  Changes in serologic markers of hepatitis B following autologous hematopoietic stem cell transplantation.

Authors:  Ji Eun Uhm; Kihyun Kim; Tae Kyu Lim; Byeong-Bae Park; Sarah Park; Yong Sang Hong; Sang Cheol Lee; In Gyu Hwang; Kwang Cheol Koh; Mark H Lee; Jin Seok Ahn; Won Seog Kim; Chul Won Jung; Won Ki Kang
Journal:  Biol Blood Marrow Transplant       Date:  2007-04       Impact factor: 5.742

Review 5.  Hepatitis B virus and hepatitis C virus dual infection.

Authors:  Gaia Caccamo; Francesca Saffioti; Giovanni Raimondo
Journal:  World J Gastroenterol       Date:  2014-10-28       Impact factor: 5.742

6.  Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: risk factors and outcome.

Authors:  M Mikulska; L Nicolini; A Signori; G Rivoli; V Del Bono; A M Raiola; C Di Grazia; A Dominietto; R Varaldo; A Ghiso; A Bacigalupo; C Viscoli
Journal:  Clin Microbiol Infect       Date:  2014-03-29       Impact factor: 8.067

7.  HBV superinfection in HCV chronic carriers: a disease that is frequently severe but associated with the eradication of HCV.

Authors:  Evangelista Sagnelli; Nicola Coppola; Mariantonietta Pisaturo; Addolorata Masiello; Gilda Tonziello; Caterina Sagnelli; Vincenzo Messina; Pietro Filippini
Journal:  Hepatology       Date:  2009-04       Impact factor: 17.425

8.  Spontaneous elimination of hepatitis C virus infection: a retrospective study on demographic, clinical, and serological correlates.

Authors:  Perdita Wietzke-Braun; Larissa-Bettina Manhardt; Albert Rosenberger; Angela Uy; Giuliano Ramadori; Sabine Mihm
Journal:  World J Gastroenterol       Date:  2007-08-21       Impact factor: 5.742

9.  Impact of occult hepatitis B virus infection on the outcome of chronic hepatitis C.

Authors:  Giovanni Squadrito; Irene Cacciola; Angela Alibrandi; Teresa Pollicino; Giovanni Raimondo
Journal:  J Hepatol       Date:  2013-06-07       Impact factor: 25.083

10.  Clearance of HCV RNA following acute hepatitis A superinfection.

Authors:  B Cacopardo; G Nunnari; L Nigro
Journal:  Dig Liver Dis       Date:  2008-01-07       Impact factor: 4.088
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