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Literature DB >> 28235193

What Came First-the Virus or the Egg?

Abstract

Three recent studies find that the single-pass transmembrane protein HAP2 mediates gamete fusion and is remarkably similar to class II fusion proteins found in viruses such as dengue and Zika.

Entities: Gene

Mesh：

Substances：
Membrane Proteins

Year: 2017 PMID： 28235193 DOI： 10.1016/j.cell.2017.02.012

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

9 in total

1. Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.

Authors: David Moi; Shunsuke Nishio; Xiaohui Li; Clari Valansi; Mauricio Langleib; Nicolas G Brukman; Kateryna Flyak; Christophe Dessimoz; Daniele de Sanctis; Kathryn Tunyasuvunakool; John Jumper; Martin Graña; Héctor Romero; Pablo S Aguilar; Luca Jovine; Benjamin Podbilewicz
Journal: Nat Commun Date: 2022-07-06 Impact factor: 17.694

2. COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells.

Authors: Liu Wenzhong; Li Hualan
Journal: Immunol Res Date: 2021-08-19 Impact factor: 2.829

Review 3. Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.

Authors: Felix A Rey; Shee-Mei Lok
Journal: Cell Date: 2018-03-08 Impact factor: 41.582

4. HAP2/GCS1: Mounting evidence of our true biological EVE?

Authors: Theodore Clark
Journal: PLoS Biol Date: 2018-08-20 Impact factor: 8.029

Review 5. How cells fuse.

Authors: Nicolas G Brukman; Berna Uygur; Benjamin Podbilewicz; Leonid V Chernomordik
Journal: J Cell Biol Date: 2019-04-01 Impact factor: 10.539

What Came First-the Virus or the Egg?

1. Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.

2. COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells.

Review 3. Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.

4. HAP2/GCS1: Mounting evidence of our true biological EVE?

Review 5. How cells fuse.

Review 6. HAP2-Mediated Gamete Fusion: Lessons From the World of Unicellular Eukaryotes.

7. Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2.

8. The AFF-1 exoplasmic fusogen is required for endocytic scission and seamless tube elongation.

9. Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes.