A Chauveau1,2,3, M-L Dalphin1, F Mauny3,4, V Kaulek3,5, E Schmausser-Hechfellner6, H Renz7, J Riedler8, J Pekkanen9,10, A M Karvonen9, R Lauener11,12, C Roduit11,13, D A Vuitton14, E von Mutius6,15, J-C Dalphin3,5. 1. Pediatrics Department, University Hospital of Besançon, Besançon, France. 2. Pediatric Allergy Department, University Hospital of Nancy, Nancy, France. 3. UMR 6249 Chrono-Environment, CNRS and University of Franche-Comté, Besançon, France. 4. Clinical Methodology Center, University Hospital of Besançon, Besançon, France. 5. Respiratory Diseases Department, University Hospital of Besançon, Besançon, France. 6. Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany. 7. Institute for Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany. 8. Children's Hospital Schwarzach, Salzburg, Austria. 9. Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland. 10. Department of Public Health, University of Helsinki, Helsinki, Finland. 11. Christine Kühne Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. 12. Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland. 13. University Children's Hospital Zurich, Zurich, Switzerland. 14. EA 3181, University of Franche-Comté, Besançon, France. 15. CPC-M, Member of the German Center for Lung Research, Giessen, Germany.
Abstract
BACKGROUND: Accurate assessment of atopic sensitization is pivotal to clinical practice and research. Skin prick test (SPT) and specific IgE (sIgE) are often used interchangeably. Some studies have suggested a disagreement between these two methods, and little is known about their association with allergic diseases. The aims of our study were to evaluate agreement between SPT and sIgE, and to compare their association with allergic diseases in 10-year-old children. METHODS: Skin prick test, sIgE measurements, and assessment of allergic diseases were performed in children aged 10 years in the Protection against Allergy: STUdy in Rural Environments (PASTURE) cohort. The agreement between SPT and sIgE was assessed by Cohen's kappa coefficient with different cutoff values. RESULTS: Skin prick tests and sIgE were performed in 529 children. The highest agreement (κ=.44) was found with a cutoff value of 3 and 5 mm for SPT, and 3.5 IU/mL for sIgE. The area under the curve (AUC) obtained with SPT was not significantly different from that obtained with sIgE. For asthma and hay fever, SPT (cutoff value at 3 mm) had a significantly higher specificity (P<.0001) than sIgE (cutoff value at 0.35 IU/mL) and the specificity was not different between both tests (P=.1088). CONCLUSION: Skin prick test and sIgE display moderate agreement, but have a similar AUC for allergic diseases. At the cutoff value of 3 mm for SPT and 0.35 IU/mL for sIgE, SPT has a higher specificity for asthma and hay fever than sIgE without difference for sensitivity.
BACKGROUND: Accurate assessment of atopic sensitization is pivotal to clinical practice and research. Skin prick test (SPT) and specific IgE (sIgE) are often used interchangeably. Some studies have suggested a disagreement between these two methods, and little is known about their association with allergic diseases. The aims of our study were to evaluate agreement between SPT and sIgE, and to compare their association with allergic diseases in 10-year-old children. METHODS: Skin prick test, sIgE measurements, and assessment of allergic diseases were performed in children aged 10 years in the Protection against Allergy: STUdy in Rural Environments (PASTURE) cohort. The agreement between SPT and sIgE was assessed by Cohen's kappa coefficient with different cutoff values. RESULTS: Skin prick tests and sIgE were performed in 529 children. The highest agreement (κ=.44) was found with a cutoff value of 3 and 5 mm for SPT, and 3.5 IU/mL for sIgE. The area under the curve (AUC) obtained with SPT was not significantly different from that obtained with sIgE. For asthma and hay fever, SPT (cutoff value at 3 mm) had a significantly higher specificity (P<.0001) than sIgE (cutoff value at 0.35 IU/mL) and the specificity was not different between both tests (P=.1088). CONCLUSION: Skin prick test and sIgE display moderate agreement, but have a similar AUC for allergic diseases. At the cutoff value of 3 mm for SPT and 0.35 IU/mL for sIgE, SPT has a higher specificity for asthma and hay fever than sIgE without difference for sensitivity.
Authors: J Bousquet; C A Akdis; C Grattan; P A Eigenmann; K Hoffmann-Sommergruber; P W Hellings; I Agache Journal: Clin Transl Allergy Date: 2018-11-27 Impact factor: 5.871
Authors: Ha Thi Chu; Isabelle Godin; Nguyễn Thanh Phương; Lan Huu Nguyen; Tran Thi Mong Hiep; Ngo Minh Xuan; Francis Corazza; Olivier Michel Journal: Asia Pac Allergy Date: 2018-10-23
Authors: Freerk Prenzel; Regina Treudler; Tobias Lipek; Maike Vom Hove; Paula Kage; Simone Kuhs; Thorsten Kaiser; Maximilian Bastl; Jan Bumberger; Jon Genuneit; Thomas Hornick; Stefan Klotz; Julia Zarnowski; Maren Boege; Veit Zebralla; Jan-Christoph Simon; Susanne Dunker Journal: J Asthma Allergy Date: 2022-09-01