Jorge Ruiz-Medrano1, José M Ruiz-Moreno2,3, Abhilash Goud4, Kiran Kumar Vupparaboina5, Soumya Jana5, Jay Chhablani4. 1. Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland. 2. Department of Ophthalmology, Castilla La Mancha University, Albacete, Spain. 3. Vissum Corporation, Spain. 4. Smt. Kanuri Santhamma Retina Vitreous Centre, L V Prasad Eye Institute, Hyderabad, India. 5. Department of Electrical Engineering, Indian Institute of Technology Hyderabad, Telangana, India.
Abstract
PURPOSE: To analyze the vascular density of the choroid in a healthy population using swept-source optical coherence tomography. METHODS: A cross-sectional, noninterventional study. INCLUSION CRITERIA: best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, no systemic or ocular diseases, and ages ranging between 3 and 85 years. One hundred and thirty-six eyes from 136 subjects were analyzed, 86 eyes (63.2%) were from male and 50 eyes (36.8%) from female subjects. The eyes were divided into different age groups to analyze the possible age-related changes. Twelve-millimeter horizontal, fovea-centered B-scans were used. Choroidal stroma and vessel area analysis involved automated segmentation and binarization using validated algorithms. RESULTS: Mean age was 33.1 ± 24.5 years. Mean choroidal area was 0.5554 ± 0.1377 mm. Mean stromal area was 0.2524 ± 0.0762 mm, and mean vascular region area was 0.3029 ± 0.0893 mm. The percentage of choroidal vascularity (vascular area/total area) was 54.40 ± 8.35%. Choroid area, vascular region, and percentage of choroidal vascular density were statistically higher in the <18-year-old group versus the >18-year-old group (P < 0.001). The stromal region was not different (P = 0.46). In the same way, choroid area, vascular region, and percentage of choroidal vascular density between the 5 age groups were statistically different (P < 0.001), showing larger figures in the 0 to 10-year-old group, but not stromal region (P = 0.71). There were no gender-related differences. CONCLUSION: The luminal area and the percentage of vascular/total area decrease with increasing age, while the stromal area remains stable.
PURPOSE: To analyze the vascular density of the choroid in a healthy population using swept-source optical coherence tomography. METHODS: A cross-sectional, noninterventional study. INCLUSION CRITERIA: best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, no systemic or ocular diseases, and ages ranging between 3 and 85 years. One hundred and thirty-six eyes from 136 subjects were analyzed, 86 eyes (63.2%) were from male and 50 eyes (36.8%) from female subjects. The eyes were divided into different age groups to analyze the possible age-related changes. Twelve-millimeter horizontal, fovea-centered B-scans were used. Choroidal stroma and vessel area analysis involved automated segmentation and binarization using validated algorithms. RESULTS: Mean age was 33.1 ± 24.5 years. Mean choroidal area was 0.5554 ± 0.1377 mm. Mean stromal area was 0.2524 ± 0.0762 mm, and mean vascular region area was 0.3029 ± 0.0893 mm. The percentage of choroidal vascularity (vascular area/total area) was 54.40 ± 8.35%. Choroid area, vascular region, and percentage of choroidal vascular density were statistically higher in the <18-year-old group versus the >18-year-old group (P < 0.001). The stromal region was not different (P = 0.46). In the same way, choroid area, vascular region, and percentage of choroidal vascular density between the 5 age groups were statistically different (P < 0.001), showing larger figures in the 0 to 10-year-old group, but not stromal region (P = 0.71). There were no gender-related differences. CONCLUSION: The luminal area and the percentage of vascular/total area decrease with increasing age, while the stromal area remains stable.
Authors: Hao Zhou; Yining Dai; Yingying Shi; Jonathan F Russell; Cancan Lyu; Jila Noorikolouri; William J Feuer; Zhongdi Chu; Qinqin Zhang; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Ophthalmol Retina Date: 2019-10-01
Authors: Mohammed A Rasheed; Niroj K Sahoo; Abhilash Goud; Kiran K Vupparaboina; Jay Chhablani Journal: Indian J Ophthalmol Date: 2018-12 Impact factor: 1.848