Highly Networked Capsular Silica-Porphyrin Hybrid Nanostructures as Efficient Materials for Acetone Vapor Sensing.

The development of novel functional nanomaterials is critically important for the further evolution of advanced chemical sensor technology. For this purpose, metalloporphyrins offer unique binding properties as host molecules that can be tailored at the synthetic level and potentially improved by incorporation into inorganic materials. In this work, we present a novel hybrid nanosystem based on a highly networked silica nanoarchitecture conjugated through covalent bonding to an organic functional molecule, a tetraphenylporphyrin derivative, and its metal complexes. The sensing properties of the new hybrid materials were studied using a nanomechanical membrane-type surface stress sensor (MSS) with acetone and nitric oxide as model analytes. This hybrid inorganic-organic MSS-based system exhibited excellent performance for acetone sensing at low operating temperatures (37 °C), making it available for diagnostic monitoring. The hybridization of an inorganic substrate of large surface area with organic molecules of various functionalities results in sub-ppm detection of acetone vapors. Acetone is an important metabolite in lipid metabolism and can also be present in industrial environments at deleterious levels. Therefore, we believe that the analysis system presented by our work represents an excellent opportunity for the development of a portable, easy-to-use device for monitoring local acetone levels.