Bernardo Sopeña1, Alberto Rivera2, Antonio Chamorro3, Mayka Freire2, Vanessa Alende4, Elena Seco3, Miguel A González-Gay5, Arturo González-Quintela6. 1. Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain; Departamento de Medicina, Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Electronic address: bsopena@gmail.com. 2. Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, Spain. 3. Department of Medicine, Facultad de Medicina, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain. 4. Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain. 5. Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Facultad de Medicina Universidad de Cantabria, Santander, Spain. 6. Departamento de Medicina Interna, Hospital Clínico Universitario, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña 15706, Spain; Departamento de Medicina, Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
Abstract
OBJECTIVE: To perform a systematic review of all cases of the association between Kikuchi's disease (KD) and systemic lupus erythematosus (SLE), and to ascertain the clinical and laboratory characteristics of this association (KD-SLE). METHODS: We conducted a systematic search of the scientific literature until 31 January 2016. For study purposes, only patients aged >14 years, with histologically proven KD, definite SLE and adequate clinical data were included. To compare KD-SLE against isolated KD and SLE, we selected 2 large series of patients with KD and 4 series of SLE patients. RESULTS: The search found 158 adults with proven KD-SLE. Of these, 113 with sufficient clinical information were included; 86 were women (female:male ratio = 5.0); mean age at diagnosis was 34 years (range: 14-56 years); and an ethnic distribution of 50.5% Asian, 34% Caucasian, and 15% other. KD-SLE patients differed significantly from patients with isolated KD, presenting with a higher frequency of high fever (90%), severe KD (88%), and extranodal manifestations. When compared to patients with SLE, those with KD-SLE presented with a higher frequency of fever and systemic symptoms and a lower frequency of lupus nephritis (22%). SLE had been diagnosed before KD in 18% of cases, simultaneously in 51%, and after KD in 31%. No significant differences were found in terms of time of diagnosis. CONCLUSIONS: While KD-SLE patients share many clinical and laboratory manifestations with SLE, they differ in a lower frequency of lupus nephritis. The relative time of diagnosis of each disease did not affect the clinical expression of KD-SLE.
OBJECTIVE: To perform a systematic review of all cases of the association between Kikuchi's disease (KD) and systemic lupus erythematosus (SLE), and to ascertain the clinical and laboratory characteristics of this association (KD-SLE). METHODS: We conducted a systematic search of the scientific literature until 31 January 2016. For study purposes, only patients aged >14 years, with histologically proven KD, definite SLE and adequate clinical data were included. To compare KD-SLE against isolated KD and SLE, we selected 2 large series of patients with KD and 4 series of SLEpatients. RESULTS: The search found 158 adults with proven KD-SLE. Of these, 113 with sufficient clinical information were included; 86 were women (female:male ratio = 5.0); mean age at diagnosis was 34 years (range: 14-56 years); and an ethnic distribution of 50.5% Asian, 34% Caucasian, and 15% other. KD-SLEpatients differed significantly from patients with isolated KD, presenting with a higher frequency of high fever (90%), severe KD (88%), and extranodal manifestations. When compared to patients with SLE, those with KD-SLE presented with a higher frequency of fever and systemic symptoms and a lower frequency of lupus nephritis (22%). SLE had been diagnosed before KD in 18% of cases, simultaneously in 51%, and after KD in 31%. No significant differences were found in terms of time of diagnosis. CONCLUSIONS: While KD-SLEpatients share many clinical and laboratory manifestations with SLE, they differ in a lower frequency of lupus nephritis. The relative time of diagnosis of each disease did not affect the clinical expression of KD-SLE.
Authors: Jorge Hurtado-Díaz; María Lucero Espinoza-Sánchez; Eduardo Rojas-Milán; Erik Cimé-Aké; María de Los Ángeles Macias; Lizeth Romero-Ibarra; Olga Lidia Vera-Lastra Journal: Am J Case Rep Date: 2021-03-07
Authors: Karolina I Smolag; Marcus Fager Ferrari; Eva Zetterberg; Eva Leinoe; Torben Ek; Anna M Blom; Maria Rossing; Myriam Martin Journal: Front Immunol Date: 2021-11-09 Impact factor: 7.561