Andrea V Cuc1, Dona E C Locke1, Noah Duncan2, Julie A Fields3, Charlene Hoffman Snyder4, Sherrie Hanna3, Angela Lunde3, Glenn E Smith5, Melanie Chandler6. 1. Division of Psychology, Mayo Clinic Arizona, Phoenix, AZ, USA. 2. Naval Hospital Jacksonville, Jacksonville, FL, USA. 3. Division of Neurocognitive Disorders, Mayo Clinic Rochester, Rochester, MN, USA. 4. Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA. 5. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. 6. Division of Psychology, Mayo Clinic Florida, Jacksonville, FL, USA.
Abstract
OBJECTIVE: This study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden. METHODS: A randomized controlled pilot trial was performed. RESULTS: At 6 months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6 months. There were no statistically significant differences on anxiety, quality of life, or burden outcomes in this small pilot trial; however, effect sizes were moderate, suggesting that the sample sizes in this pilot study were not adequate to detect statistical significance. CONCLUSION: Either form of cognitive rehabilitation may help partners' mood, compared with providing no treatment. However, effect size estimates related to other partner outcomes (i.e., burden, quality of life, and anxiety) suggest that follow-up efficacy trials will need sample sizes of at least 30-100 people per group to accurately determine significance.
RCT Entities:
OBJECTIVE: This study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden. METHODS: A randomized controlled pilot trial was performed. RESULTS: At 6 months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6 months. There were no statistically significant differences on anxiety, quality of life, or burden outcomes in this small pilot trial; however, effect sizes were moderate, suggesting that the sample sizes in this pilot study were not adequate to detect statistical significance. CONCLUSION: Either form of cognitive rehabilitation may help partners' mood, compared with providing no treatment. However, effect size estimates related to other partner outcomes (i.e., burden, quality of life, and anxiety) suggest that follow-up efficacy trials will need sample sizes of at least 30-100 people per group to accurately determine significance.
Authors: Marilyn S Albert; Steven T DeKosky; Dennis Dickson; Bruno Dubois; Howard H Feldman; Nick C Fox; Anthony Gamst; David M Holtzman; William J Jagust; Ronald C Petersen; Peter J Snyder; Maria C Carrillo; Bill Thies; Creighton H Phelps Journal: Alzheimers Dement Date: 2011-04-21 Impact factor: 21.566
Authors: Stephen R Wisniewski; Steven H Belle; David W Coon; Susan M Marcus; Marcia G Ory; Louis D Burgio; Robert Burns; Richard Schulz Journal: Psychol Aging Date: 2003-09
Authors: Melanie C Greenaway; Sherrie M Hanna; Susan W Lepore; Glenn E Smith Journal: Am J Alzheimers Dis Other Demen Date: 2008 Oct-Nov Impact factor: 2.035