Noëlla Rajonson1,2, David Meless3,4, Boubacar Ba5, Malick Faye6, Jean-Serge Diby7, Serge N'zore8, Sébastien Datté8, Lucrèce Diecket9, Clémentine N'Diaye10, Edmond Addi Aka11, Kouadio Kouakou12, Abou Ba6, Didier Koumavi Ekouévi4, François Dabis2,13, Caroline Shiboski14, Elise Arrivé1,2. 1. Université de Bordeaux, UFR, d'Odontologie, Bordeaux, France. 2. INSERM, ISPED, Centre INSERM U1219-Bordeaux Population Health, Bordeaux, France. 3. Universite Felix Houphouet-Boigny, UFR d'Odontostomatologie, Abidjan, Côte d'Ivoire. 4. Programme PAC-CI/CHU de Treichville, Abidjan, Côte d'Ivoire. 5. Centre d'Odonto-Stomatologie, Bamako, Mali. 6. Hopital d'Enfants Albert Royer, Dakar, Senegal. 7. PMI Yopougon-Attié, Abidjan, Côte d'Ivoire. 8. Université de Cocody, CCTOS, Cocody, Abidjan, Côte d'Ivoire. 9. CHU Yopougon, Pédiatrie, Yopougon, Abidjan, Côte d'Ivoire. 10. Hôpital Gabriel Touré, Pédiatrie, Medina Coure, Bamako, Mali. 11. CePReF, Pédiatrie, Abidjan, Côte d'Ivoire. 12. CIRBA, Pédiatrie, Abidjan, Côte d'Ivoire. 13. Université Bordeaux, ISPED, Centre INSERM U1219- Epidémiologie-Biostatistique, Bordeaux, France. 14. Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Abstract
INTRODUCTION: The objectives of this study were to investigate the association between HIV infection and dental caries among children in West Africa, and to identify factors associated with dental caries among HIV-infected children. METHODS: We conducted a multi-center cross-sectional study in Mali, Senegal and Côte d'Ivoire with a random sample of HIV-infected children aged 5-15 years on antiretroviral therapy and their uninfected siblings. A standardized examination was performed by calibrated dentists. The association between the number of decayed, missing or filled permanent and primary teeth surfaces (DMFdefS) and HIV status was investigated by fitting multivariable zero-inflated negative binomial models, for each age group (<12 and ≥12 years). Factors associated with dental caries could be investigated only for HIV-infected children <12 years old. RESULTS: The sample included 420 HIV-infected children and 418 non-infected siblings. The median DMFdefS was 7 for the HIV-infected children and 2 for the uninfected siblings. The proportion of children with DMFdefS ≥1 was significantly higher among the HIV-infected children than uninfected children (86.0 percent versus 64.4 percent, P < 0.001). The HIV-infected children were less likely to be caries-free than the uninfected siblings in both age groups. We found a higher degree of caries experience among HIV-infected children < 12 years old, in whom it was associated with sweet drink consumption, history of night bottle use, immunosuppression, and younger age at study entry. CONCLUSIONS: Although preventable, the burden of dental disease was high in children from families affected by HIV in West Africa and was associated with HIV infection and immunosuppression.
INTRODUCTION: The objectives of this study were to investigate the association between HIV infection and dental caries among children in West Africa, and to identify factors associated with dental caries among HIV-infectedchildren. METHODS: We conducted a multi-center cross-sectional study in Mali, Senegal and Côte d'Ivoire with a random sample of HIV-infectedchildren aged 5-15 years on antiretroviral therapy and their uninfected siblings. A standardized examination was performed by calibrated dentists. The association between the number of decayed, missing or filled permanent and primary teeth surfaces (DMFdefS) and HIV status was investigated by fitting multivariable zero-inflated negative binomial models, for each age group (<12 and ≥12 years). Factors associated with dental caries could be investigated only for HIV-infectedchildren <12 years old. RESULTS: The sample included 420 HIV-infectedchildren and 418 non-infected siblings. The median DMFdefS was 7 for the HIV-infectedchildren and 2 for the uninfected siblings. The proportion of children with DMFdefS ≥1 was significantly higher among the HIV-infectedchildren than uninfected children (86.0 percent versus 64.4 percent, P < 0.001). The HIV-infectedchildren were less likely to be caries-free than the uninfected siblings in both age groups. We found a higher degree of caries experience among HIV-infectedchildren < 12 years old, in whom it was associated with sweet drink consumption, history of night bottle use, immunosuppression, and younger age at study entry. CONCLUSIONS: Although preventable, the burden of dental disease was high in children from families affected by HIV in West Africa and was associated with HIV infection and immunosuppression.
Authors: M O Coker; E F Mongodin; S S El-Kamary; P Akhigbe; O Obuekwe; A Omoigberale; P Langenberg; C Enwonwu; L Hittle; W A Blattner; M Charurat Journal: Sci Rep Date: 2020-07-02 Impact factor: 4.379
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Authors: Vincent P Richards; Modupe O Coker; Paul Akhigbe; Nneka M Chukwumah; Morenike Oluwatoyin Folayan; Kimon Divaris; Ozoemene Obuekwe; Augustine Omoigberale; Elima Jedy-Agba; Michael Kim; Manhattan E Charurat Journal: BMC Oral Health Date: 2022-09-27 Impact factor: 3.747