| Literature DB >> 28232217 |
Zhen Tan1, Jinlian Zhao1, Jimei Liu1, Min Zhang1, Ridao Chen1, Kebo Xie1, Jungui Dai2.
Abstract
Eleven new sesquiterpenoids, including eight cadinane-type sesquiterpenoids, Ganodermanol A-H (1-8), and three eudesmane-type sesquiterpenoids, Ganodermanol I-K (9-11), together with three known compounds (12-14), were isolated from the cultured mycelia of Ganoderma capense. Their structures and absolute configurations were identified through combined extensive spectroscopic analysis, circular dichroism (CD), and Mo2(AcO)4-induced CD. Compounds 4 and 9 exhibited moderate cytotoxic activity against the human cancer cell line HCT116 with IC50 values of 16.6 and 12.2μM, respectively.Entities:
Keywords: 12,rel-(+)-(2aR,5R,5aR,8S,8aS,8bR)-decahydro-2,2,5,8-tetramethyl-2H-naphtho[1,8-bc] furan-5-ol (PubChem CID: 12047671); Bluemenol A (PubChem CID: 5280462); Cultured mycelia; Ganoderma capense; Ganodermanol; Sesquiterpenoids
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Year: 2017 PMID： 28232217 DOI： 10.1016/j.fitote.2017.02.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882