| Literature DB >> 28231521 |
Mohd Javed Naim1, Md Jahangir Alam1, Shujauddin Ahmad1, Farah Nawaz1, Neelima Shrivastava1, Meeta Sahu1, Ozair Alam2.
Abstract
Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR's (Peroxisome proliferator activated receptor). Exhaustive research has led to determination of its vast biological profile with wide range of therapeutic applications. This review covers recent pharmacological advancements of thiazolidinedione moiety along with structure activity relationship so as to provide better correlation among different structures and their receptor interactions.Entities:
Keywords: Anticancer; Antihyperglycemic; Antimicrobial; PPARγ; Thiazolidinedione
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Year: 2017 PMID： 28231521 DOI： 10.1016/j.ejmech.2017.02.031
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514