Literature DB >> 2823110

Genetic rescue of muscle defects associated with a mutant Drosophila melanogaster tropomyosin allele.

E A Fyrberg1, C C Karlik.   

Abstract

We describe a genetic transformation system which should prove useful for investigating tropomyosin assembly and function. Muscle abnormalities associated with a defective tropomyosin allele were corrected by integrating the wild-type gene into germ line chromosomes. The transformation protocol permits application of directed mutagenesis techniques in investigations of contractile regulatory mechanisms.

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Year:  1987        PMID： 2823110      PMCID： PMC367918          DOI： 10.1128/mcb.7.8.2977-2980.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  16 in total

1.  Two Drosophila melanogaster tropomyosin genes: structural and functional aspects.

Authors:  C C Karlik; E A Fyrberg
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

2.  An insertion within a variably spliced Drosophila tropomyosin gene blocks accumulation of only one encoded isoform.

Authors:  C C Karlik; E A Fyrberg
Journal:  Cell       Date:  1985-05       Impact factor: 41.582

3.  Analysis of P transposable element functions in Drosophila.

Authors:  R E Karess; G M Rubin
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

4.  Genetic Variability of Flight Metabolism in DROSOPHILA MELANOGASTER. I. Characterization of Power Output during Tethered Flight.

Authors:  J W Curtsinger; C C Laurie-Ahlberg
Journal:  Genetics       Date:  1981-07       Impact factor: 4.562

5.  Isolation of Drosophila flightless mutants which affect myofibrillar proteins of indirect flight muscle.

Authors:  K Mogami; Y Hotta
Journal:  Mol Gen Genet       Date:  1981

6.  Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C.

Authors:  J R Pearlstone; L B Smillie
Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

7.  Low Mr tropomyosin isoforms from chicken brain and intestinal epithelium have distinct actin-binding properties.

Authors:  K O Broschat; D R Burgess
Journal:  J Biol Chem       Date:  1986-10-05       Impact factor: 5.157

8.  Amino acid sequence of equine platelet tropomyosin. Correlation with interaction properties.

Authors:  W G Lewis; G P Cote; A S Mak; L B Smillie
Journal:  FEBS Lett       Date:  1983-06-13       Impact factor: 4.124

9.  Transformation of white locus DNA in drosophila: dosage compensation, zeste interaction, and position effects.

Authors:  T Hazelrigg; R Levis; G M Rubin
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

10.  Vectors for P element-mediated gene transfer in Drosophila.

Authors:  G M Rubin; A C Spradling
Journal:  Nucleic Acids Res       Date:  1983-09-24       Impact factor: 16.971
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  1 in total

1.  A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant.

Authors:  R C Miller; R Schaaf; D W Maughan; T R Tansey
Journal:  J Muscle Res Cell Motil       Date:  1993-02       Impact factor: 2.698
  1 in total

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