Literature DB >> 2822969

The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells.

M A Bedell1, K H Jones, L A Laimins.   

Abstract

Plasmids containing the E6 and E7 open reading frames of human papillomavirus type 18 expressed from an autologous transcriptional control region were sufficient for transformation of NIH 3T3 and Rat-1 cells. Transformation by these sequences did not always involve morphological alterations even though anchorage-independent growth occurred at a high frequency. In these cells, the efficiency of transformation by the E6 and E7 construct was equivalent to or, in most cases, better than that observed with the entire viral genome. These data indicate that a major human papillomavirus type 18 transforming function is localized in either the E6 or E7 gene products or both.

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Mesh：

Year:  1987        PMID： 2822969      PMCID： PMC255968          DOI： 10.1128/JVI.61.11.3635-3640.1987

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  A quantitative in vitro focus assay for bovine papilloma virus.

Authors:  I Dvoretzky; R Shober; S K Chattopadhyay; D R Lowy
Journal:  Virology       Date:  1980-06       Impact factor: 3.616

2.  Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.

Authors:  S T Cole; O Danos
Journal:  J Mol Biol       Date:  1987-02-20       Impact factor: 5.469

3.  Bovine papillomavirus contains multiple transforming genes.

Authors:  Y C Yang; H Okayama; P M Howley
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

4.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.

Authors:  E Schwarz; U K Freese; L Gissmann; W Mayer; B Roggenbuck; A Stremlau; H zur Hausen
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

5.  Identification of a second transforming region in bovine papillomavirus DNA.

Authors:  J T Schiller; W C Vass; D R Lowy
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

6.  Localization and analysis of bovine papillomavirus type 1 transforming functions.

Authors:  N Sarver; M S Rabson; Y C Yang; J C Byrne; P M Howley
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103

7.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

8.  The transforming function of bovine papillomavirus DNA.

Authors:  Y Nakabayashi; S K Chattopadhyay; D R Lowy
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

9.  A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

Authors:  M Dürst; L Gissmann; H Ikenberg; H zur Hausen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

Authors:  M Boshart; L Gissmann; H Ikenberg; A Kleinheinz; W Scheurlen; H zur Hausen
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598
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  67 in total

Review 1.  Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression.

Authors:  Oishee Chakrabarti; Sudhir Krishna
Journal:  J Biosci       Date:  2003-04       Impact factor: 1.826

2.  Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

Authors:  W C Phelps; K Münger; C L Yee; J A Barnes; P M Howley
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

Review 3.  Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.

Authors:  Aloysius J Klingelhutz; Ann Roman
Journal:  Virology       Date:  2012-01-27       Impact factor: 3.616

4.  Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18.

Authors:  D Gius; S Grossman; M A Bedell; L A Laimins
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

5.  Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.

Authors:  W C Phelps; S Bagchi; J A Barnes; P Raychaudhuri; V Kraus; K Münger; P M Howley; J R Nevins
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

6.  The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.

Authors:  Sandy S Tungteakkhun; Maria Filippova; Jonathan W Neidigh; Nadja Fodor; Penelope J Duerksen-Hughes
Journal:  J Virol       Date:  2008-07-16       Impact factor: 5.103

7.  Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.

Authors:  P Auewarakul; L Gissmann; A Cid-Arregui
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding.

Authors:  M C McIntyre; M G Frattini; S R Grossman; L A Laimins
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

9.  The full-length isoform of human papillomavirus 16 E6 and its splice variant E6* bind to different sites on the procaspase 8 death effector domain.

Authors:  Sandy S Tungteakkhun; Maria Filippova; Nadja Fodor; Penelope J Duerksen-Hughes
Journal:  J Virol       Date:  2009-11-11       Impact factor: 5.103

10.  In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.

Authors:  M S Barbosa; W C Vass; D R Lowy; J T Schiller
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103
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