Literature DB >> 28228835

Recurrent Alternate-Sided Homonymous Hemianopia Due to Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes (MELAS): A Case Report.

Kristen M Krysko1, Arun N E Sundaram2.   

Abstract

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) can rarely cause alternate-sided homonymous hemianopia due to stroke-like episodes involving the occipital lobes, as reported in three previously published cases. The authors report an interesting case of a 16-year-old presenting with myoclonic epilepsy due to MELAS with the rare ND3 mitochondrial mutation T10191C, with recurrent alternate-sided homonymous hemianopia. Visual field and corresponding magnetic resonance imaging (MRI) findings are presented. To the authors' knowledge, this is the first report of recurrent alternate-sided homonymous hemianopia in MELAS with documented visual field and MRI findings with resolution between each episode.

Entities:  

Keywords:  Case report; MELAS; mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes; recurrent alternate-sided homonymous hemianopia

Year:  2016        PMID: 28228835      PMCID: PMC5278788          DOI: 10.1080/01658107.2016.1224256

Source DB:  PubMed          Journal:  Neuroophthalmology        ISSN: 0165-8107


  9 in total

1.  MELAS: recurrent reversible hemianopia.

Authors:  S Aaron; A Anupriya; M Sunithi; V Mathew; T Maya; M K Goyal; M Alexander
Journal:  Neurol India       Date:  2010 Sep-Oct       Impact factor: 2.117

2.  Evolution of brain imaging abnormalities in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.

Authors:  Wenya Linda Bi; Joachim M Baehring; Robert L Lesser
Journal:  J Neuroophthalmol       Date:  2006-12       Impact factor: 3.042

3.  MELAS: a nationwide prospective cohort study of 96 patients in Japan.

Authors:  Shuichi Yatsuga; Nataliya Povalko; Junko Nishioka; Koju Katayama; Noriko Kakimoto; Toyojiro Matsuishi; Tatsuyuki Kakuma; Yasutoshi Koga
Journal:  Biochim Biophys Acta       Date:  2011-04-02

4.  Mutations in mitochondrially encoded complex I enzyme as the second common cause in a cohort of Chinese patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes.

Authors:  Danhua Zhao; Daojun Hong; Wei Zhang; Sheng Yao; Xiaokun Qi; He Lv; Riliang Zheng; Liqun Feng; Yining Huang; Yun Yuan; Zhaoxia Wang
Journal:  J Hum Genet       Date:  2011-08-18       Impact factor: 3.172

5.  Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene.

Authors:  R W Taylor; R Singh-Kler; C M Hayes; P E Smith; D M Turnbull
Journal:  Ann Neurol       Date:  2001-07       Impact factor: 10.422

Review 6.  MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options.

Authors:  Ayman W El-Hattab; Adekunle M Adesina; Jeremy Jones; Fernando Scaglia
Journal:  Mol Genet Metab       Date:  2015-06-15       Impact factor: 4.797

Review 7.  Melas: an original case and clinical criteria for diagnosis.

Authors:  M Hirano; E Ricci; M R Koenigsberger; R Defendini; S G Pavlakis; D C DeVivo; S DiMauro; L P Rowland
Journal:  Neuromuscul Disord       Date:  1992       Impact factor: 4.296

8.  Alternate-sided homonymous hemianopia as the solitary presentation of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes syndrome.

Authors:  Wan-Ya Su; Ling-Yuh Kao; Sien-Tsong Chen
Journal:  Chang Gung Med J       Date:  2003-03

9.  Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations.

Authors:  B Koo; L E Becker; S Chuang; F Merante; B H Robinson; D MacGregor; I Tein; V B Ho; D A McGreal; J R Wherrett
Journal:  Ann Neurol       Date:  1993-07       Impact factor: 10.422

  9 in total
  2 in total

Review 1.  Cerebral imaging in paediatric mitochondrial disorders.

Authors:  Josef Finsterer; Sinda Zarrouk-Mahjoub
Journal:  Neuroradiol J       Date:  2018-07-06

2.  Leigh-Like Syndrome With a Novel, Complex Phenotype Due to m.10191T>C in Mt-ND3.

Authors:  Shaundra M Newstead; Josef Finsterer
Journal:  Cureus       Date:  2022-09-09
  2 in total

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