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Literature DB >> 28228272

Commanding CNS Invasion: GM-CSF.

Junjie Zhao¹, Lillian Sun², Xiaoxia Li³.

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF or Csf-2) is a pro-inflammatory mediator implicated in the pathogenesis of various autoimmune diseases. In this issue of Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 28228272 PMCID： PMC6172037 DOI： 10.1016/j.immuni.2017.02.003

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

9 in total

1. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

Authors: Mohamed El-Behi; Bogoljub Ciric; Hong Dai; Yaping Yan; Melissa Cullimore; Farinaz Safavi; Guang-Xian Zhang; Bonnie N Dittel; Abdolmohamad Rostami
Journal: Nat Immunol Date: 2011-04-24 Impact factor: 25.606

2. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

Authors: Laura Codarri; Gabor Gyülvészi; Vinko Tosevski; Lysann Hesske; Adriano Fontana; Laurent Magnenat; Tobias Suter; Burkhard Becher
Journal: Nat Immunol Date: 2011-04-24 Impact factor: 25.606

3. Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.

Authors: Zizhen Kang; Chenhui Wang; Jarod Zepp; Ling Wu; Kevin Sun; Junjie Zhao; Unni Chandrasekharan; Paul E DiCorleto; Bruce D Trapp; Richard M Ransohoff; Xiaoxia Li
Journal: Nat Neurosci Date: 2013-09-01 Impact factor: 24.884

4. Immunology: In the beginning.

Authors: Richard M Ransohoff
Journal: Nature Date: 2009-11-05 Impact factor: 49.962

Review 5. GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation.

Authors: Burkhard Becher; Sonia Tugues; Melanie Greter
Journal: Immunity Date: 2016-11-15 Impact factor: 31.745

6. IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.

Authors: Yan Hu; Naruhisa Ota; Ivan Peng; Canio J Refino; Dimitry M Danilenko; Patrick Caplazi; Wenjun Ouyang
Journal: J Immunol Date: 2010-03-15 Impact factor: 5.422

7. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.

Authors: Zizhen Kang; Cengiz Zubeyir Altuntas; Muhammet Fatih Gulen; Caini Liu; Natalia Giltiay; Hongwei Qin; Liping Liu; Wen Qian; Richard M Ransohoff; Cornelia Bergmann; Stephen Stohlman; Vincent K Tuohy; Xiaoxia Li
Journal: Immunity Date: 2010-03-18 Impact factor: 31.745

8. The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

Authors: Andrew L Croxford; Margit Lanzinger; Felix J Hartmann; Bettina Schreiner; Florian Mair; Pawel Pelczar; Björn E Clausen; Steffen Jung; Melanie Greter; Burkhard Becher
Journal: Immunity Date: 2015-09-01 Impact factor: 31.745

9. Fate mapping of IL-17-producing T cells in inflammatory responses.

Authors: Keiji Hirota; João H Duarte; Marc Veldhoen; Eve Hornsby; Ying Li; Daniel J Cua; Helena Ahlfors; Christoph Wilhelm; Mauro Tolaini; Ursula Menzel; Anna Garefalaki; Alexandre J Potocnik; Brigitta Stockinger
Journal: Nat Immunol Date: 2011-01-30 Impact factor: 25.606

9 in total

5 in total

Commanding CNS Invasion: GM-CSF.

1. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

2. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

3. Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.

4. Immunology: In the beginning.

Review 5. GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation.

6. IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.

7. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.

8. The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

9. Fate mapping of IL-17-producing T cells in inflammatory responses.

1. IFN-γ promotes transendothelial migration of CD4⁺ T cells across the blood-brain barrier.

2. NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.

Review 3. Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis.

Review 4. Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update.

5. Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis.