| Literature DB >> 2822753 |
J W Almond1, G D Westrop, D M Evans, G Dunn, P D Minor, D Magrath, G C Schild.
Abstract
The genetic basis of attenuation of the poliovirus type 3 vaccine strain P3/Leon 12a1b has been investigated by comparing the nucleotide sequence of this strain with that of its neurovirulent progenitor P3/Leon/37 and by constructing recombinants between these two viruses using infectious cDNAs. Preliminary results suggest that attenuation is caused by just two point mutations, one occurring in the 5' non-coding region and the other causing an amino acid change in coat protein VP3.Entities:
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Year: 1987 PMID： 2822753 DOI： 10.1016/0166-0934(87)90081-4
Source DB: PubMed Journal: J Virol Methods ISSN： 0166-0934 Impact factor: 2.014