Eduardo Lazcano-Ponce1, Gregorio Katz1,2, Rocío Rodríguez-Valentín1, Filipa de Castro1, Betania Allen-Leigh1, María Elena Márquez-Caraveo3, Miguel Ángel Ramírez-García3, Eduardo Arroyo-García3, María Elena Medina-Mora4, Gustavo Ángeles5, José Edmundo Urquieta-Salomón6, Luis Salvador-Carulla7. 1. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México. 2. Departamento de Salud Mental, Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México. 3. Hospital Psiquiátrico Infantil Dr. Juan N. Navarro. Ciudad de México, México. 4. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz. Ciudad de México, México. 5. Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill. North Carolina, USA. 6. Dirección de Indicadores y Análisis de Información Gubernamental, Instituto Nacional de Estadística y Geografía (Inegi). Ciudad de México, México. 7. Brain and Mind Centre, The University of Sydney. Sydney, Australia.
Abstract
OBJECTIVE: : This study aims to generate evidence on intellectual development disorders (IDD) in Mexico. MATERIALS AND METHODS: : IDD disease burden will be estimated with a probabilistic model, using population-based surveys. Direct and indirect costs of catastrophic expenses of families with a member with an IDD will be evaluated. Genomic characterization of IDD will include: sequencing participant exomes and performing bioinformatics analyses to identify de novo or inherited variants through trio analysis; identifying genetic variants associated with IDD, and validating randomly selected variants by polymerase chain reaction (PCR) and sequencing or real-time quantitative PCR (qPCR). Delphi surveys will be done on best practices for IDD diagnosis and management. An external evaluation will employ qualitative case studies of two social and labor inclusion programs for people with IDD. CONCLUSIONS: : The results will constitute scientific evidence for the design, promotion and evaluation of public policies, which are currently absent on IDD.
OBJECTIVE: : This study aims to generate evidence on intellectual development disorders (IDD) in Mexico. MATERIALS AND METHODS: : IDD disease burden will be estimated with a probabilistic model, using population-based surveys. Direct and indirect costs of catastrophic expenses of families with a member with an IDD will be evaluated. Genomic characterization of IDD will include: sequencing participant exomes and performing bioinformatics analyses to identify de novo or inherited variants through trio analysis; identifying genetic variants associated with IDD, and validating randomly selected variants by polymerase chain reaction (PCR) and sequencing or real-time quantitative PCR (qPCR). Delphi surveys will be done on best practices for IDD diagnosis and management. An external evaluation will employ qualitative case studies of two social and labor inclusion programs for people with IDD. CONCLUSIONS: : The results will constitute scientific evidence for the design, promotion and evaluation of public policies, which are currently absent on IDD.