Literature DB >> 2822548

Copper-catalyzed DNA damage by ascorbate and hydrogen peroxide: kinetics and yield.

R Stoewe1, W A Prütz.   

Abstract

Time profiles for degradation of DNA via reaction of H2O2 with the DNA-Cu+ complex were analyzed over a wide range of concentrations of the components. The yield of DNA damage per H2O2 molecule is 10 times lower than that obtained with gamma-radiolytically generated .OH radicals. The observations can be explained by a model in which H2O2 reacts, slowly on the one hand with DNA-Cu+ by formation of toxic .OH radicals immediately at the DNA and faster on the other hand with Cu+ in the bulk solution by formation of less toxic Cu(III) intermediates.

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Year:  1987        PMID： 2822548     DOI： 10.1016/s0891-5849(87)80003-5

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  17 in total

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4.  Development of immunoblotting techniques for DNA radical detection.

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5.  Effects of metal ion chelators on DNA strand breaks and inactivation produced by hydrogen peroxide in Escherichia coli: detection of iron-independent lesions.

Authors:  N R Asad; A C Leitão
Journal:  J Bacteriol       Date:  1991-04       Impact factor: 3.490

6.  Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.

Authors:  Dong-Hyun Lee; Timothy R O'Connor; Gerd P Pfeifer
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7.  Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.

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8.  Interaction between glutathione and Cu(II) in the vicinity of nucleic acids.

Authors:  W A Prütz
Journal:  Biochem J       Date:  1994-09-01       Impact factor: 3.857

9.  Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide.

Authors:  O I Aruoma; B Halliwell; E Gajewski; M Dizdaroglu
Journal:  Biochem J       Date:  1991-02-01       Impact factor: 3.857

10.  Mutagenesis by the autoxidation of iron with isolated DNA.

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