Agata Szpera-Goździewicz1, Maciej Majcherek2, Maciej Boruczkowski2, Tomasz Goździewicz3, Grzegorz Dworacki2, Lukasz Wicherek4, Grzegorz Henryk Bręborowicz1. 1. Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland. 2. Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland. 3. Department of Gynecology, Poznan University of Medical Sciences, Poznan, Poland. 4. Department of Oncology, Radiotherapy and Gynecological Oncology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Abstract
PROBLEM: We tested the hypothesis that the number of both CECs and CEPCs as well as the vWf blood plasma concentration are altered in pregnant women with hypertensive disorders. METHOD OF STUDY: Seventy-five pregnant women were enrolled in our study. We used multicolor flow cytometry for CEC and CEPC analysis and the commercial human VWF ELISA kit to measure vWf blood plasma concentration. RESULTS: The highest number of CECs was found in the chronic hypertension group and the lowest number in the healthy pregnant control group. The highest number of CEPCs was found in the control group and the lowest number in the chronic hypertension group. The vWf blood plasma concentration was the highest in the pre-eclampsia group. The CEPC/CEC ratio reached its lowest value in the chronic hypertension group and its highest value in the control group. CONCLUSION: The number of both CECs and CEPCs as well as the vWf blood plasma concentration depends on the type of hypertension complicating the pregnancy.
PROBLEM: We tested the hypothesis that the number of both CECs and CEPCs as well as the vWf blood plasma concentration are altered in pregnant women with hypertensive disorders. METHOD OF STUDY: Seventy-five pregnant women were enrolled in our study. We used multicolor flow cytometry for CEC and CEPC analysis and the commercial humanVWF ELISA kit to measure vWf blood plasma concentration. RESULTS: The highest number of CECs was found in the chronic hypertension group and the lowest number in the healthy pregnant control group. The highest number of CEPCs was found in the control group and the lowest number in the chronic hypertension group. The vWf blood plasma concentration was the highest in the pre-eclampsia group. The CEPC/CEC ratio reached its lowest value in the chronic hypertension group and its highest value in the control group. CONCLUSION: The number of both CECs and CEPCs as well as the vWf blood plasma concentration depends on the type of hypertension complicating the pregnancy.
Authors: Mai He; Hooman Mirzakhani; Ling Chen; Robert Wu; Augusto A Litonjua; Leonard Bacharier; Scott T Weiss; D Michael Nelson Journal: Endocrinology Date: 2020-06-01 Impact factor: 4.736