Tommaso Fasano1, Thelma A Pertinhez2,3, Lorenzo Tribi4, Daniela Lasagni2, Annalisa Pilia1, Luigi Vecchia1, Roberto Baricchi2, Giovanni Bianchin4. 1. Clinical Chemistry and Endocrinology Laboratory, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy. 2. Transfusion Medicine Unit, Arcispedale Santa Maria Nuova- Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy. 3. Department of Biomedical, Biotechnological, and Translational Sciences, University of Parma, Parma, Italy. 4. Department of Otolaryngology and Audiology, Arcispedale Santa Maria Nuova-Scientific Institute for Research, Hospitalization and Health Care, Reggio Emilia, Italy.
Abstract
OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. STUDY DESIGN: Prospective case-control study. METHODS: One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity. A clinical laboratory assessment was completed on blood samples collected from SSHL patients and control subjects. Multivariable regression analysis was performed to investigate the association between laboratory data and SSHL basis. RESULTS: Only a few SSHL patients were positive for autoimmunity or viral infection. Statistically significant (P < .05) higher levels of blood glucose, glycated hemoglobin (HbA1C), lipoprotein (a), and factor VIII were found in SSHL patients compared to controls. Furthermore, blood glucose, HbA1C, uric acid, factor VIII, and homocysteine were significantly associated to disease severity. CONCLUSIONS: Gluco-metabolic, lipidic, and coagulative laboratory data support the vascular hypothesis for SSHL and its severity. LEVEL OF EVIDENCE: 3b Laryngoscope, 127:2375-2381, 2017.
OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. STUDY DESIGN: Prospective case-control study. METHODS: One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity. A clinical laboratory assessment was completed on blood samples collected from SSHL patients and control subjects. Multivariable regression analysis was performed to investigate the association between laboratory data and SSHL basis. RESULTS: Only a few SSHL patients were positive for autoimmunity or viral infection. Statistically significant (P < .05) higher levels of blood glucose, glycated hemoglobin (HbA1C), lipoprotein (a), and factor VIII were found in SSHL patients compared to controls. Furthermore, blood glucose, HbA1C, uric acid, factor VIII, and homocysteine were significantly associated to disease severity. CONCLUSIONS: Gluco-metabolic, lipidic, and coagulative laboratory data support the vascular hypothesis for SSHL and its severity. LEVEL OF EVIDENCE: 3b Laryngoscope, 127:2375-2381, 2017.
Authors: So Young Kim; Jee Hye Wee; Chanyang Min; Dae-Myoung Yoo; Hyo Geun Choi Journal: Int J Environ Res Public Health Date: 2020-09-05 Impact factor: 3.390