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Literature DB >> 2822460

Metabolic iteration, evolution and cognition in cellular proliferation.

Abstract

A model for cellular proliferation is described according to which proliferation ensues when metabolism evolves towards commitment to DNA synthesis, and inhibition of proliferation occurs when enzymic interactions are iterated within a few metabolic pathways, another limiting factor being the supply of metabolites. The model successfully describes cellular growth and division as a 'cognitive process' based on interaction within enzymic elements and the genome, and affords an explanation in these terms of some empirical phenomena which have previously been understood only as isolated observations.

Mesh：

Substances：
Enzymes
DNA
Cyclic AMP

Year: 1987 PMID： 2822460 DOI： 10.1007/BF01956046

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

91 in total

Review 1. Control of growth of mammalian cells in cell culture.

Authors: R W Holley
Journal: Nature Date: 1975-12-11 Impact factor: 49.962

2. Relation between cell growth and cell division. III. Changes in nuclear volume and growth rate and prevention of cell division in Amoeba proteus resulting from cytoplasmic amputations.

Authors: D M PRESCOTT
Journal: Exp Cell Res Date: 1956-08 Impact factor: 3.905

3. On the origin of cancer cells.

Authors: O WARBURG
Journal: Science Date: 1956-02-24 Impact factor: 47.728

4. Structuredness of the cytoplasmic matrix and Michaelis-Menten constants for the hydrolysis of FDA during the cell cycle in Chinese hamster ovary cells.

Authors: L Cercek; B Cercek; C H Ockey
Journal: Biophysik Date: 1973

9. Phorbol myristate acetate (PMA) suppresses polarization and locomotion and alters F-actin content of Walker carcinosarcoma cells.

Authors: H U Keller; A Zimmermann; H Cottier
Journal: Int J Cancer Date: 1985-10-15 Impact factor: 7.396

10. Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis.

Authors: N Feuerstein; H L Cooper
Journal: J Biol Chem Date: 1983-09-10 Impact factor: 5.157

1 in total

1. A unifying model of the cell proliferation emphasizing plasma membrane fluxes.

Authors: E Cervén
Journal: Experientia Date: 1990-10-15

1 in total

Metabolic iteration, evolution and cognition in cellular proliferation.

Review 1. Control of growth of mammalian cells in cell culture.

2. Relation between cell growth and cell division. III. Changes in nuclear volume and growth rate and prevention of cell division in Amoeba proteus resulting from cytoplasmic amputations.

3. On the origin of cancer cells.

4. Structuredness of the cytoplasmic matrix and Michaelis-Menten constants for the hydrolysis of FDA during the cell cycle in Chinese hamster ovary cells.

5. Restoration of normal growth by covering of agglutinin sites on tumour cell surface.

6. Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

7. On the stability of cognitive processes.

8. The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.

9. Phorbol myristate acetate (PMA) suppresses polarization and locomotion and alters F-actin content of Walker carcinosarcoma cells.

10. Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis.

1. A unifying model of the cell proliferation emphasizing plasma membrane fluxes.