Literature DB >> 2822444

Are increases in GABAB receptors consistent findings following chronic antidepressant administration?

J A Cross1, R W Horton.   

Abstract

Desmethylimipramine and zimelidine (10 mg/kg) were administered to rats once daily for 21 days. Chronic desmethylimipramine significantly reduced the number of 5HT2 binding sites in the frontal cortex but not hippocampus while chronic zimelidine did not affect 5HT2 binding in either brain region. The number and affinity of GABAB binding sites in the frontal cortex were unaltered by either drug.

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Year:  1987        PMID： 2822444     DOI： 10.1016/0014-2999(87)90425-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

Review 1.  Neurochemical and metabolic aspects of antidepressants: an overview.

Authors:  G B Baker; R T Coutts; A J Greenshaw
Journal:  J Psychiatry Neurosci       Date:  2000-11       Impact factor: 6.186

2.  Differential effects of chronic antidepressants in behavioural tests of beta-adrenergic and GABAB receptor function.

Authors:  D J McManus; A J Greenshaw
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 3.  Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.

Authors:  G B Baker; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1989-03       Impact factor: 5.046

4.  Decreased gamma-aminobutyric acid (GABA) modulatory effect on rat vas deferens neurotransmission after chronic administration of imipramine.

Authors:  G H Strobel; J B Calixto; G Ballejo
Journal:  Cell Mol Neurobiol       Date:  1989-12       Impact factor: 5.046

5.  The GABA(A) receptor complex as a target for fluoxetine action.

Authors:  G Tunnicliff; N L Schindler; G J Crites; R Goldenberg; A Yochum; E Malatynska
Journal:  Neurochem Res       Date:  1999-10       Impact factor: 3.996

6.  Solubilization and characterization of GABAB receptor binding sites from porcine brain synaptic membranes.

Authors:  M Facklam; N G Bowery
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain.

Authors:  K G Todd; D J McManus; G B Baker
Journal:  Cell Mol Neurobiol       Date:  1995-06       Impact factor: 5.046

Review 8.  Innovative approaches for the development of antidepressant drugs: current and future strategies.

Authors:  Lee E Schechter; Robert H Ring; Chad E Beyer; Zoë A Hughes; Xavier Khawaja; Jessica E Malberg; Sharon Rosenzweig-Lipson
Journal:  NeuroRx       Date:  2005-10

9.  Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5-HT2 binding site changes.

Authors:  J A Cross; R W Horton
Journal:  Br J Pharmacol       Date:  1988-02       Impact factor: 8.739
  9 in total

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