Shahzad M Ali1,2,3,4,5, Timothy M Pawlik2, Miguel A Rodriguez-Bigas4, John R T Monson5, George J Chang3, David W Larson6. 1. Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, 55905, USA. 2. Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, OH, USA. 3. Colon and Rectal Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA. 4. The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230-1402, USA. 5. College of Medicine, University of Central Florida, 2501 North Orange Avenue, Orlando, FL, USA. 6. College of Medicine, University of Central Florida, 2501 North Orange Avenue, Orlando, FL, USA. larson.david2@mayo.edu.
Abstract
PURPOSE AND DESIGN: Optimal surgical strategy for resectable synchronous colorectal cancer with liver metastasis (SCRLM) remains a therapeutic dilemma. Multiple retrospective studies including several meta-analyses have been published since 2001 to help facilitate the decision making process and identify the optimal surgical approach. Controversy limits the generalization of available data to draw conclusions. A review of available literature on appropriate surgical timing may alleviate confusion among physicians and promote a more evidence based approach. RESULTS AND CONCLUSION: Current evidence supports the feasibility, safety, and equivalent oncological outcomes of simultaneous curative resection of stage IV colorectal cancer with liver metastasis in appropriately selected patients.
PURPOSE AND DESIGN: Optimal surgical strategy for resectable synchronous colorectal cancer with liver metastasis (SCRLM) remains a therapeutic dilemma. Multiple retrospective studies including several meta-analyses have been published since 2001 to help facilitate the decision making process and identify the optimal surgical approach. Controversy limits the generalization of available data to draw conclusions. A review of available literature on appropriate surgical timing may alleviate confusion among physicians and promote a more evidence based approach. RESULTS AND CONCLUSION: Current evidence supports the feasibility, safety, and equivalent oncological outcomes of simultaneous curative resection of stage IV colorectal cancer with liver metastasis in appropriately selected patients.