Literature DB >> 2822428

Neurotoxicity of prophylactic cranial irradiation in patients with small cell carcinoma of the lung.

A Twijnstra1, P J Boon, A C Lormans, G P ten Velde.   

Abstract

This study is concerned with effects of prophylactic cranial irradiation on neurological and mental functioning of patients with small cell cancer of the lung. Results are reported of a pilot study in two parts. In a prospective clinical-neurological study, 14 patients with small cell cancer of the lung were evaluated with standard neurological and bedside mental status examinations, before and after irradiation. Their performance was compared with evaluation results of seven small cell cancer of the lung patients who received no irradiation. Dysfunctions were exclusively found in the irradiated patients, which are interpreted as a contributional effect of prophylactic cranial irradiation. Results are reported of further neuropsychological investigation in a sample of five prophylactic cranial irradiation patients. The presence of a rather specific pattern of neuropsychic deficits was confirmed. Areas of malfunctioning were described with some clinical and research implications.

Entities:  

Mesh：

Year:  1987        PMID： 2822428     DOI： 10.1016/0277-5379(87)90345-2

Source DB:  PubMed          Journal:  Eur J Cancer Clin Oncol        ISSN： 0277-5379


  10 in total

1.  Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer: a study of event related potentials.

Authors:  C Parageorgiou; C Dardoufas; V Kouloulias; E Ventouras; N Uzunoglu; L Vlahos; A Rambavilas; G Christodoulou
Journal:  J Neurooncol       Date:  2000-12       Impact factor: 4.130

2.  The role of ifosfamide and cyclophosphamide in the multi-modality treatment after surgery for cure for small-cell bronchial carcinomas (SCLC).

Authors:  K Karrer; H Denck; H Karnicka-Mlodkowska; P Drings; J Orel; G M Salzer; M Thermann; A Lattuneddu; Y Sun; E Hata
Journal:  Med Oncol Tumor Pharmacother       Date:  1989

3.  Molecular pathways: radiation-induced cognitive impairment.

Authors:  Dana Greene-Schloesser; Elizabeth Moore; Mike E Robbins
Journal:  Clin Cancer Res       Date:  2013-02-06       Impact factor: 12.531

Review 4.  Radiation-induced cognitive impairment--from bench to bedside.

Authors:  Dana Greene-Schloesser; Mike E Robbins
Journal:  Neuro Oncol       Date:  2012-09       Impact factor: 12.300

5.  Cellular response of the rat brain to single doses of (137)Cs γ rays does not predict its response to prolonged 'biologically equivalent' fractionated doses.

Authors:  Dana M Greene-Schloesser; Mitra Kooshki; Valerie Payne; Ralph B D'Agostino; Kenneth T Wheeler; Linda J Metheny-Barlow; Mike E Robbins
Journal:  Int J Radiat Biol       Date:  2014-09       Impact factor: 2.694

Review 6.  A critical review of the clinical effects of therapeutic irradiation damage to the brain: the roots of controversy.

Authors:  Carol L Armstrong; Kunsang Gyato; Abdel W Awadalla; Robert Lustig; Zelig A Tochner
Journal:  Neuropsychol Rev       Date:  2004-03       Impact factor: 7.444

7.  The value of computed tomographic (CT) scan surveillance in the detection and management of brain metastases in patients with small cell lung cancer.

Authors:  J Hardy; I Smith; G Cherryman; M Vincent; I Judson; T Perren; M Williams
Journal:  Br J Cancer       Date:  1990-10       Impact factor: 7.640

8.  Treatment of radiation-induced brain injury with bisdemethoxycurcumin.

Authors:  Yun-Qian Chang; Gui-Juan Zhou; Hong-Mei Wen; Duan-Qun He; Chen-Lin Xu; Ya-Rui Chen; Yi-Hui Li; Shuang-Xi Chen; Zi-Jian Xiao; Ming Xie
Journal:  Neural Regen Res       Date:  2023-02       Impact factor: 6.058

9.  Radiation-induced brain injury: A review.

Authors:  Dana Greene-Schloesser; Mike E Robbins; Ann M Peiffer; Edward G Shaw; Kenneth T Wheeler; Michael D Chan
Journal:  Front Oncol       Date:  2012-07-19       Impact factor: 6.244

10.  The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation.

Authors:  Caroline I Schnegg; Dana Greene-Schloesser; Mitra Kooshki; Valerie S Payne; Fang-Chi Hsu; Mike E Robbins
Journal:  Free Radic Biol Med       Date:  2013-03-14       Impact factor: 8.101
  10 in total

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