Fei Chen1, Yaqi Duan2, Yongqin Li3, Wenjie Han4, Weilei Shi4, Weiwei Zhang4, Yonghua Huang5. 1. Department of Neurology, General Hospital of Beijing Military Command, Beijing, China; Department of Neurology, Haidian Hospital, Beijing, China. 2. Department of Medical Ultrasonics, General Hospital of Beijing Military Command, Beijing, China. 3. Department of Neurology, General Hospital of Beijing Military Command, Beijing, China; Department of Neurology, Anhui Medical University, Hefei, China. 4. Department of Neurology, General Hospital of Beijing Military Command, Beijing, China. 5. Department of Neurology, General Hospital of Beijing Military Command, Beijing, China. Electronic address: huangyh88@yeah.net.
Abstract
BACKGROUND: Epilepsy is a common complication of cranioplasty. The present study was designed to explore the clinical effect of prophylactic anti-epilepsy drugs (AED) to control epileptic seizures associated with cranioplasty. METHODS: and design: This trial was a prospective, randomized, open-label, single-centre, active controlled study designed to investigate the use of antiepileptic drug to control epileptic seizures associated with cranioplasty. We tested the necessity and methods of drug use. Three hundred twenty epilepsy patients who underwent cranioplasty were included in this study. The patients were randomly divided into the control group (160 cases) and the experimental group (160 cases). AED were administered to experimental group from 4 days before the surgery until 1 month after the surgery. The incidence of early and late epileptic seizures after cranioplasty was analyzed. The liver function, abnormal blood test 1 month after surgery were compared between these two groups. RESULTS: The incidence of seizures in the Control group was 28.6% (43 cases in 149 cases) while in the experimental group was only 5.9% (9 cases in 151 cases), which had statistical significance. The incidence of epileptic seizure was significantly higher in patients who received no AED treatment than in those who received AED treatment. Besides, the abnormal liver function and blood routine examination in both control and experimental group had no significant differences. CONCLUSION: The incidence of epilepsy associated with the cranioplasty is high and early use of anti-epileptic drugs can effectively reduce the occurrence of seizures.
RCT Entities:
BACKGROUND:Epilepsy is a common complication of cranioplasty. The present study was designed to explore the clinical effect of prophylactic anti-epilepsy drugs (AED) to control epilepticseizures associated with cranioplasty. METHODS: and design: This trial was a prospective, randomized, open-label, single-centre, active controlled study designed to investigate the use of antiepileptic drug to control epilepticseizures associated with cranioplasty. We tested the necessity and methods of drug use. Three hundred twenty epilepsypatients who underwent cranioplasty were included in this study. The patients were randomly divided into the control group (160 cases) and the experimental group (160 cases). AED were administered to experimental group from 4 days before the surgery until 1 month after the surgery. The incidence of early and late epilepticseizures after cranioplasty was analyzed. The liver function, abnormal blood test 1 month after surgery were compared between these two groups. RESULTS: The incidence of seizures in the Control group was 28.6% (43 cases in 149 cases) while in the experimental group was only 5.9% (9 cases in 151 cases), which had statistical significance. The incidence of epilepticseizure was significantly higher in patients who received no AED treatment than in those who received AED treatment. Besides, the abnormal liver function and blood routine examination in both control and experimental group had no significant differences. CONCLUSION: The incidence of epilepsy associated with the cranioplasty is high and early use of anti-epileptic drugs can effectively reduce the occurrence of seizures.
Authors: H Mee; F Anwar; I Timofeev; N Owens; K Grieve; G Whiting; K Alexander; K Kendrick; A Helmy; P Hutchinson; A Kolias Journal: Front Surg Date: 2022-05-17