Literature DB >> 2822291

Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity.

W R Carper1, R C Dorey, J H Beber.   

Abstract

We investigated the effect of disulfiram (Antabuse) on the activity of alcohol dehydrogenase (EC 1.1.1.1) in vitro. We observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (EC 1.2.1.3). These results suggest a possible explanation for various side effects observed in the clinical use of Antabuse.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2822291

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  3 in total

1.  Disulfiram inhibits the in vitro growth of methicillin-resistant staphylococcus aureus.

Authors:  M Phillips; G Malloy; D Nedunchezian; A Lukrec; R G Howard
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

2.  The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.

Authors:  Juliana Almeida-Silva; Diego Silva Menezes; Juan Mateus Pereira Fernandes; Márcio Cerqueira Almeida; Deyvison Rhuan Vasco-Dos-Santos; Roberto Magalhães Saraiva; Alessandra Lifsitch Viçosa; Sandra Aurora Chavez Perez; Sônia Gumes Andrade; Ana Márcia Suarez-Fontes; Marcos André Vannier-Santos
Journal:  Front Cell Infect Microbiol       Date:  2022-07-29       Impact factor: 6.073

3.  High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

Authors:  Irina Bancos; John Paul Bida; Defeng Tian; Mary Bundrick; Kristen John; Molly Nelson Holte; Yeng F Her; Debra Evans; Dyana T Saenz; Eric M Poeschla; Derek Hook; Gunda Georg; L James Maher
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.