Literature DB >> 28222310

Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans.

Christiana G Martin1, Hyungsuk Kim2, Sijung Yun3, Whitney Livingston2, Joseph Fetta2, Vincent Mysliwiec4, Tristin Baxter4, Jessica M Gill5.   

Abstract

Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones. PTSD is associated with miRNAs that regulate biological functions including neuronal activities, suggesting that they play a role in PTSD symptomatology. Published by Elsevier B.V.

Entities:  

Keywords:  Biomarker; Micro RNA; PTSD

Mesh：

Substances：

Year:  2017        PMID： 28222310      PMCID： PMC6065100          DOI： 10.1016/j.psychres.2017.01.081

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  43 in total

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5.  High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABAAR-δ receptor levels.

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6.  microRNA mir-598-3p mediates susceptibility to stress enhancement of remote fear memory.

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9.  Integrated Analysis of miRNA and mRNA Expression Profiles Reveals the Molecular Mechanism of Posttraumatic Stress Disorder and Therapeutic Drugs.

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10.  What Happened in the Hippocampal Axon in a Rat Model of Posttraumatic Stress Disorder.

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