| Literature DB >> 28219791 |
Jie Xiang1, Jinxia Hu2, Tong Shen2, Bin Liu3, Fang Hua2, Kun Zan2, Jie Zu2, Guiyun Cui4, Xinchun Ye5.
Abstract
Our previous studies have found that stem cells conditioned medium (CM) facilitated functional recovery after stroke in non-diabetics. However, whether bone marrow stromal cells conditioned medium (BMSCs-CM) treatment after stroke in type 2 diabetic (T2DM) rats improve functional outcomes remains unclear. T2DM rats were induced and subjected to stroke then treated with or without BMSCs-CM. Functional outcomes and blood-brain barrier (BBB) leakage were performed, the expression of Angiopoietin (Ang) 1 and tyrosine kinase (Tie) 2 were also assessed. Our results showed that BMSCs-CM treatment significantly improved functional outcomes, decreased BBB leakage and the expression of Ang1 and Tie2 were also changed after BMSCs-CM treatment in type 2 diabetes after stroke. In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.Entities:
Keywords: Angiopoietin 1; Bone marrow stromal cells; Ischemic stroke; Type 2 diabetes mellitus; Tyrosine kinase 2
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Year: 2017 PMID： 28219791 DOI： 10.1016/j.neulet.2017.02.040
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046