Literature DB >> 28219526

Antifungal activity of ionic liquids based on (-)-menthol: a mechanism study.

Jakub Suchodolski1, Joanna Feder-Kubis2, Anna Krasowska3.   

Abstract

The mechanism of toxicity of chiral ionic liquids with (1R,2S,5R)-(-)-menthol [Cn-Am-Men][Cl] (n=10, 11 or 12) in the fungus Candida albicans is reported here. Ionic liquids were more toxic towards Candida strain lacking all identified multidrug resistance efflux pumps. Moreover, the compounds tested inhibited C. albicans filamentation at the concentration at which detached fungal cells also adhered to the plastic surface. Our results showed the high activity of all the tested chiral ionic liquids in the permeabilization of C. albicans' membranes and in the digestion and interruption of the cell wall. The investigated ionic liquids thus have potential as disinfectants because besides their antifungal and antiadhesive action these compounds do not cause hemolysis.
Copyright © 2017 Elsevier GmbH. All rights reserved.

Entities:  

Keywords:  Antifungal activity; Candida albicans; Cell wall destruction; Ionic liquids; Membrane permeabilisation

Mesh：

Substances：

Year:  2017        PMID： 28219526     DOI： 10.1016/j.micres.2016.12.008

Source DB:  PubMed          Journal:  Microbiol Res        ISSN： 0944-5013            Impact factor:   5.415


  18 in total

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4.  The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B.

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