Literature DB >> 2821915

Asbestos catalyzes the formation of the 6-oxobenzo[a]pyrene radical from 6-hydroxybenzo[a]pyrene.

P Graceffa1, S A Weitzman.   

Abstract

Crocidolite asbestos catalyzes the oxidation of 6-hydroxybenzo[a]pyrene, a metabolite of benzo[a]pyrene, to the 6-oxobenzo[a]pyrene radical as determined by electron spin resonance spectroscopy. This may be a mechanism whereby inhaled asbestos enhances the incidence of lung cancer induced by cigarette smoke, which contains benzo[a]pyrene.

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Year:  1987        PMID: 2821915     DOI: 10.1016/0003-9861(87)90594-7

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN: 0003-9861            Impact factor:   4.013


  2 in total

1.  Cooperative stimulation by sulfite and crocidolite asbestos fibres of enzyme catalyzed production of reactive oxygen species.

Authors:  E F Elstner; W Schütz; G Vogl
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

2.  Effect of coexposure to asbestos and kerosene soot on pulmonary drug-metabolizing enzyme system.

Authors:  J M Arif; S G Khan; N Mahmood; M Aslam; Q Rahman
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031

  2 in total

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