Literature DB >> 28217909

Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma.

Sanja Ninic1, Marija Kalaba1, Bosiljka Jovicic1, Vladislav Vukomanovic1,2, Sergej Prijic1,2, Biljana Vucetic1, Ruzica Kravljanac1,2, Ana Vujic3,4, Jovan Kosutic1,2.   

Abstract

Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway (mTOR) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  arrhythmia; m-TOR inhibitor; rhabdomyoma; sirolimus

Mesh：

Substances：

Year:  2017        PMID： 28217909      PMCID： PMC6931800          DOI： 10.1111/anec.12435

Source DB:  PubMed          Journal:  Ann Noninvasive Electrocardiol        ISSN： 1082-720X            Impact factor:   1.468


  12 in total

1.  Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia.

Authors:  Christina Y Miyake; Pedro J Del Nido; Mark E Alexander; Frank Cecchin; Charles I Berul; John K Triedman; Tal Geva; Edward P Walsh
Journal:  J Am Coll Cardiol       Date:  2011-10-25       Impact factor: 24.094

2.  Everolimus: a challenging drug in the treatment of multifocal inoperable cardiac rhabdomyoma.

Authors:  Haci Ahmet Demir; Filiz Ekici; Arzu Yazal Erdem; Suna Emir; Bahattin Tunç
Journal:  Pediatrics       Date:  2012-06-25       Impact factor: 7.124

3.  Rapid regression of left ventricular outflow tract rhabdomyoma after sirolimus therapy.

Authors:  Colm Breathnach; Jane Pears; Orla Franklin; David Webb; Colin J McMahon
Journal:  Pediatrics       Date:  2014-09-01       Impact factor: 7.124

Review 4.  Tuberous sclerosis and cardiac rhabdomyomas: a case report and review of the literature.

Authors:  Peace Madueme; Robert Hinton
Journal:  Congenit Heart Dis       Date:  2011-03-21       Impact factor: 2.007

5.  Regression of a cardiac rhabdomyoma in a patient receiving everolimus.

Authors:  Dana Tiberio; David N Franz; John R Phillips
Journal:  Pediatrics       Date:  2011-04-04       Impact factor: 7.124

6.  Cardiac rhabdomyomas associated with tuberous sclerosis complex in 11 children: presentation to outcome.

Authors:  Abdullah Kocabaş; Filiz Ekici; Ibrahim İlker Cetin; Suna Emir; Haci Ahmet Demir; Mehmet Emre Arı; Aydan Değerliyurt; Alev Güven
Journal:  Pediatr Hematol Oncol       Date:  2012-11-14       Impact factor: 1.969

7.  Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia.

Authors:  Funda Öztunç; Sezen U Atik; Aslı O Güneş
Journal:  Cardiol Young       Date:  2015-10       Impact factor: 1.093

8.  Efficacy and safety of a mammalian target of rapamycin inhibitor in pediatric patients with tuberous sclerosis complex: A systematic review and meta-analysis.

Authors:  Guang Yang; Lu Yang; Xiaofan Yang; Xiuyu Shi; Jing Wang; Yujie Liu; Jun Ju; Liping Zou
Journal:  Exp Ther Med       Date:  2014-11-27       Impact factor: 2.447

Review 9.  Cardiovascular manifestations of tuberous sclerosis complex and summary of the revised diagnostic criteria and surveillance and management recommendations from the International Tuberous Sclerosis Consensus Group.

Authors:  Robert B Hinton; Ashwin Prakash; Robb L Romp; Darcy A Krueger; Timothy K Knilans
Journal:  J Am Heart Assoc       Date:  2014-11-25       Impact factor: 5.501

Review 10.  Is mTOR inhibition a systemic treatment for tuberous sclerosis?

Authors:  Romina Moavero; Antonella Coniglio; Francesco Garaci; Paolo Curatolo
Journal:  Ital J Pediatr       Date:  2013-09-17       Impact factor: 2.638
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  2 in total

1.  Multiple cardiac rhabdomyomas in tuberous sclerosis complex: case report and review of the literature.

Authors:  Paula Frudit; Bruno Kusznir Vitturi; Flavia Cristina Navarro; Ivan Rondelli; Geanete Pozzan
Journal:  Autops Case Rep       Date:  2019-09-30

Review 2.  Treatment of Cardiac Rhabdomyomas with mTOR Inhibitors in Children with Tuberous Sclerosis Complex-A Systematic Review.

Authors:  Monika Sugalska; Anna Tomik; Sergiusz Jóźwiak; Bożena Werner
Journal:  Int J Environ Res Public Health       Date:  2021-05-05       Impact factor: 3.390
  2 in total

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