Literature DB >> 28217717

Dexmedetomidine-induced neuroprotection: is it translational?

Yunzhen Wang1, Ruquan Han2, Zhiyi Zuo3.   

Abstract

Dexmedetomidine is often used in anesthesia and critical care medicine practice to sedate patients. Its neuroprotective effects have been shown in various ischemic and hemorrhagic brain injury models of animals. Randomized clinical trials have indicated that dexmedetomidine can improve outcome of patients under intensive care. Clinical trials are needed to determine whether dexmedetomidine can provide neuroprotection against ischemic and hemorrhagic stroke.

Entities:  

Keywords:  Dexmedetomidine; ICU; ischemic stroke; neuroprotection

Year:  2016        PMID： 28217717      PMCID： PMC5310645     

Source DB:  PubMed          Journal:  Transl Perioper Pain Med


  15 in total

1.  Benzodiazepines inhibit neutrophil chemotaxis and superoxide production in a stimulus dependent manner; PK-11195 antagonizes these effects.

Authors:  M Finnerty; T J Marczynski; H J Amirault; M Urbancic; B R Andersen
Journal:  Immunopharmacology       Date:  1991 Nov-Dec

2.  Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole.

Authors:  W E Hoffman; E Kochs; C Werner; C Thomas; R F Albrecht
Journal:  Anesthesiology       Date:  1991-08       Impact factor: 7.892

3.  Binding of alpha-adrenergic receptors stimulates the anti-mycobacterial activity of murine peritoneal macrophages.

Authors:  B A Miles; W P Lafuse; B S Zwilling
Journal:  J Neuroimmunol       Date:  1996-12       Impact factor: 3.478

4.  Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia.

Authors:  C Maier; G K Steinberg; G H Sun; G T Zhi; M Maze
Journal:  Anesthesiology       Date:  1993-08       Impact factor: 7.892

5.  Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.

Authors:  Pratik P Pandharipande; Robert D Sanders; Timothy D Girard; Stuart McGrane; Jennifer L Thompson; Ayumi K Shintani; Daniel L Herr; Mervyn Maze; E Wesley Ely
Journal:  Crit Care       Date:  2010-03-16       Impact factor: 9.097

6.  Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors.

Authors:  Souhayl Dahmani; Andrea Paris; Virginie Jannier; Lutz Hein; Danielle Rouelle; Jens Scholz; Pierre Gressens; Jean Mantz
Journal:  Anesthesiology       Date:  2008-03       Impact factor: 7.892

7.  Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.

Authors:  Yong-Man Zhu; Can-Can Wang; Long Chen; Ling-Bo Qian; Lei-Lei Ma; Jing Yu; Man-Hua Zhu; Chuan-Yun Wen; Li-Na Yu; Min Yan
Journal:  Brain Res       Date:  2012-12-05       Impact factor: 3.252

8.  Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

Authors:  Pratik P Pandharipande; Brenda T Pun; Daniel L Herr; Mervyn Maze; Timothy D Girard; Russell R Miller; Ayumi K Shintani; Jennifer L Thompson; James C Jackson; Stephen A Deppen; Renee A Stiles; Robert S Dittus; Gordon R Bernard; E Wesley Ely
Journal:  JAMA       Date:  2007-12-12       Impact factor: 56.272

9.  Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats.

Authors:  Xiaoyan Ren; Hong Ma; Zhiyi Zuo
Journal:  J Neuroimmune Pharmacol       Date:  2016-03-02       Impact factor: 4.147

10.  Central sympatholytics prolong survival in experimental sepsis.

Authors:  Stefan Hofer; Jochen Steppan; Tanja Wagner; Benjamin Funke; Christoph Lichtenstern; Eike Martin; Bernhard M Graf; Angelika Bierhaus; Markus A Weigand
Journal:  Crit Care       Date:  2009-02-06       Impact factor: 9.097
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  12 in total

Review 1.  The Role of miRNAs in Dexmedetomidine's Neuroprotective Effects against Brain Disorders.

Authors:  Codrin-Constantin Burlacu; Maria-Adriana Neag; Andrei-Otto Mitre; Alexandru-Constantin Sirbu; Andrei-Vlad Badulescu; Anca-Dana Buzoianu
Journal:  Int J Mol Sci       Date:  2022-05-13       Impact factor: 6.208

2.  Can Dexmedetomidine Be Effective in the Protection of Radiotherapy-Induced Brain Damage in the Rat?

Authors:  Seda Çınar; Levent Tümkaya; Tolga Mercantepe; Sinan Saral; Sema Rakıcı; Adnan Yılmaz; Atilla Topçu; Ahmet Şen; Sibel Karakaş
Journal:  Neurotox Res       Date:  2021-05-31       Impact factor: 3.911

3.  An investigation of the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction.

Authors:  Jie Chen; Na Shen; Xiaohui Duan; Yaning Guo
Journal:  Exp Ther Med       Date:  2017-12-04       Impact factor: 2.447

4.  Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model.

Authors:  Wook Jeong; Hsichiang Kung; Chia Chi Cheng; Changwoo Lim; Min Jung Jung; Jaeho Lee; Doo Sik Kim; Yusom Shin
Journal:  Pain Res Manag       Date:  2017-12-13       Impact factor: 3.037

Review 5.  Neurocognitive Outcome After Treatment With(out) ECMO for Neonatal Critical Respiratory or Cardiac Failure.

Authors:  Raisa M Schiller; Dick Tibboel
Journal:  Front Pediatr       Date:  2019-11-26       Impact factor: 3.418

6.  Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43.

Authors:  Xiaoyang Zheng; Xiaoying Cai; Fang Ye; Ying Li; Qin Wang; Zhiyi Zuo; Wenqi Huang; Zhongxing Wang
Journal:  BMC Anesthesiol       Date:  2020-12-07       Impact factor: 2.217

Review 7.  Contemporary Neuroprotection Strategies during Cardiac Surgery: State of the Art Review.

Authors:  Palesa Motshabi-Chakane; Palesa Mogane; Jacob Moutlana; Gontse Leballo-Mothibi; Sithandiwe Dingezweni; Dineo Mpanya; Nqoba Tsabedze
Journal:  Int J Environ Res Public Health       Date:  2021-12-03       Impact factor: 3.390

8.  Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy.

Authors:  Zhi-Yuan Su; Qing Ye; Xian-Bao Liu; Yu-Zhong Chen; Hong Zhan; Shi-Yuan Xu
Journal:  Neural Regen Res       Date:  2017-08       Impact factor: 5.135

9.  Dexmedetomidine is superior to midazolam for sedation and cerebral protection in postoperative hypertensive intracerebral hemorrhage patients: a retrospective study.

Authors:  Weiyi Gong; Shuguang Zhang; Xiaoliang Li; Lei Shi
Journal:  J Int Med Res       Date:  2020-09       Impact factor: 1.671

10.  Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway.

Authors:  Zong Chen; Yong Ding; Ying Zeng; Xue-Ping Zhang; Jian-Yan Chen
Journal:  BMC Pharmacol Toxicol       Date:  2022-03-25       Impact factor: 2.483
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