| Literature DB >> 2821670 |
R C Cutlip1, H D Lehmkuhl, K A Brogden, M J Schmerr.
Abstract
Cell culture medium was harvested from cells infected with ovine progressive pneumonia (OPP) virus and used to prepare killed virus vaccines. Virus was inactivated by either heat, formalin, or ethyleneimine and used either without adjuvant, with Freund incomplete adjuvant, or with aluminum hydroxide adjuvant to vaccinate sheep. The sheep produced precipitating antibody against the virus but were not protected against infection when challenged with live OPP virus.Entities:
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Year: 1987 PMID： 2821670 DOI： 10.1016/0378-1135(87)90082-4
Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293