Julie D Flom1, Barbara A Cohn2, Parisa Tehranifar3, Lauren C Houghton1, Ying Wei4, Angeline Protacio1, Piera Cirillo2, Karin B Michels5, Mary Beth Terry6. 1. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY. 2. The Center for Research on Women and Children's Health, The Child Health and Development Studies, Public Health Institute, Berkeley, CA. 3. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY. 4. Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY. 5. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA; Institute for Prevention and Cancer Epidemiology, Freiburg University Medical Center, Freiburg, Germany. 6. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY; The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University Mailman School of Public Health and the New York State Psychiatric Institute, New York, NY. Electronic address: mt146@columbia.edu.
Abstract
PURPOSE: The purpose of the article was to examine the association of early life growth with age at menarche. METHODS: Using data from a prospective birth cohort (n = 1134 women, 290 sibling sets), we assessed the association between postnatal growth at 4 months, 1 year, and 4 years and age at menarche, using generalized estimating equations and generalized linear random effects models. RESULTS: Overall, 18% of the cohort experienced early menarche (<12 years). After accounting for postnatal growth in length, faster postnatal change in weight (per 10-percentile increase) in all three periods was associated with an increase (range 9%-20%) in the likelihood of having an early menarche. In adjusted linear models, faster weight gains in infancy and childhood were associated with an average age at menarche that was 1.1-1.3 months earlier compared with stable growth. The overall results were consistent for percentile and conditional growth models. Girls who experienced rapid growth (defined as increasing across two major Centers for Disease Control and Prevention growth percentiles) in early infancy had an average age at menarche that was 4.6 months earlier than girls whose growth was stable. CONCLUSIONS: Faster postnatal weight gains in infancy and early childhood before the age of 4 years are associated with earlier age at menarche.
PURPOSE: The purpose of the article was to examine the association of early life growth with age at menarche. METHODS: Using data from a prospective birth cohort (n = 1134 women, 290 sibling sets), we assessed the association between postnatal growth at 4 months, 1 year, and 4 years and age at menarche, using generalized estimating equations and generalized linear random effects models. RESULTS: Overall, 18% of the cohort experienced early menarche (<12 years). After accounting for postnatal growth in length, faster postnatal change in weight (per 10-percentile increase) in all three periods was associated with an increase (range 9%-20%) in the likelihood of having an early menarche. In adjusted linear models, faster weight gains in infancy and childhood were associated with an average age at menarche that was 1.1-1.3 months earlier compared with stable growth. The overall results were consistent for percentile and conditional growth models. Girls who experienced rapid growth (defined as increasing across two major Centers for Disease Control and Prevention growth percentiles) in early infancy had an average age at menarche that was 4.6 months earlier than girls whose growth was stable. CONCLUSIONS: Faster postnatal weight gains in infancy and early childhood before the age of 4 years are associated with earlier age at menarche.
Authors: Lauren C Houghton; Mandy Goldberg; Ying Wei; Piera M Cirillo; Barbara A Cohn; Karin B Michels; Mary Beth Terry Journal: Ann Epidemiol Date: 2018-01-10 Impact factor: 3.797
Authors: Mary Beth Terry; Barbara A Cohn; Mandy Goldberg; Julie D Flom; Ying Wei; Lauren C Houghton; Parisa Tehranifar; Jasmine A McDonald; Angeline Protacio; Piera Cirillo; Karin B Michels Journal: Am J Epidemiol Date: 2019-02-01 Impact factor: 4.897
Authors: Wenyan Li; Qin Liu; Xu Deng; Yiwen Chen; Shudan Liu; Mary Story Journal: Int J Environ Res Public Health Date: 2017-10-24 Impact factor: 3.390