| Literature DB >> 28215532 |
M S Sawant1, R E Leube2.
Abstract
Intermediate filaments are major phosphoproteins. The complex patterns of intermediate filament phosphorylation make up a poorly understood code reflecting cytoskeletal properties and cellular function through an intense crosstalk with multiple signaling pathways. This review focuses on the epithelial keratin intermediate filaments highlighting the tight-knit relationship of keratin phosphorylation and network organization during cell division and apoptosis, and the importance of keratin phosphorylation during epithelial stress responses. The occurrence of keratin phosphorylation in genetic skin diseases and acquired diseases of simple epithelial tissues in liver, pancreas, and colon will be discussed. Finally, we will review the role of keratin phosphorylation in cancer with an emphasis on migration.Entities:
Keywords: 14-3-3 protein; Cell and tumor invasion; Epidermolysis bullosa simplex; Intestinal bowel disease; Kinases; Mallory–Denk body; PRL3; Phosphatase
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Year: 2016 PMID： 28215532 DOI： 10.1016/bs.ircmb.2016.09.005
Source DB: PubMed Journal: Int Rev Cell Mol Biol ISSN： 1937-6448 Impact factor: 6.813