Zahra Sobhani 1 , Saeed Reza Nami 2 , Seyed Ahmad Emami 3 , Amirhossein Sahebkar 4 , Behjat Javadi 5 Show Affiliations »
Abstract
BACKGROUND: Cardiovascular disease (CVD) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. Medicinal plants have been used for thousands of years to treat CVD. In Traditional Persian Medicine (TPM), there is a special focus on heart diseases. Avicenna, a Persian physician of the eleventh century compiled a book devoted to this field named "The treatise on cardiac drugs" which is a compendium of TPM knowledge on CVD. Avicenna mentioned 50 cardiovascular active plants and described their therapeutic effects in the treatment of CVDs. METHODS: Here, we perform a detailed search in scientific databases to verify the cardiovascular activities of the medicinal plants suggested by Avicenna. Also, we discussed cardiovascular activities of a number of the most important suggested plants as well as their efficacy in clinical studies. Major bioactive compounds identified from these plants are also discussed. RESULTS: Pharmacological studies have revealed that the majority of these plants are effective in cardiovascular health with various mechanisms. Among them, Crocus sativus L., Cinnamomum cassia (L.) J. Presl, Punica granatum L., Ocimum basilicum L., Elettaria cardamomum (L.) Maton, Melissa officinalis L. and Phyllanthus emblica L. have proved to be more effective. CONCLUSION: The above-mentioned plants can be rich sources for developing new and effective pharmaceuticals for the treatment of CVDs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Cardiovascular disease (CVD) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. Medicinal plants have been used for thousands of years to treat CVD. In Traditional Persian Medicine (TPM), there is a special focus on heart diseases . Avicenna, a Persian physician of the eleventh century compiled a book devoted to this field named "The treatise on cardiac drugs" which is a compendium of TPM knowledge on CVD. Avicenna mentioned 50 cardiovascular active plants and described their therapeutic effects in the treatment of CVDs. METHODS: Here, we perform a detailed search in scientific databases to verify the cardiovascular activities of the medicinal plants suggested by Avicenna. Also, we discussed cardiovascular activities of a number of the most important suggested plants as well as their efficacy in clinical studies. Major bioactive compounds identified from these plants are also discussed. RESULTS: Pharmacological studies have revealed that the majority of these plants are effective in cardiovascular health with various mechanisms. Among them, Crocus sativus L ., Cinnamomum cassia (L.) J. Presl, Punica granatum L ., Ocimum basilicum L ., Elettaria cardamomum (L.) Maton , Melissa officinalis L . and Phyllanthus emblica L . have proved to be more effective. CONCLUSION: The above-mentioned plants can be rich sources for developing new and effective pharmaceuticals for the treatment of CVDs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Species
Keywords:
Curcumin; adhesionzzm321990molecules; avicenna; cardiovascular diseases; endothelial function; flow-mediated vasodilation; medicinal plants; nitroglycerin-mediated dilation; pomegranate; pulse wave velocity; saffron; traditional persian medicine
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Year: 2017
PMID： 28215156 DOI： 10.2174/1381612823666170215104101
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116