Jiyoon Kim1, Ho-Su Lee2, Sang Hyoung Park2, Suk-Kyun Yang2, Byong Duk Ye2, Dong-Hoon Yang2, Kyung-Jo Kim2, Jeong-Sik Byeon2, Yong Sik Yoon3, Chang Sik Yu3, Jihun Kim4. 1. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. 2. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. 3. Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. 4. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address: jihunkim@amc.seoul.kr.
Abstract
BACKGROUND: Colorectal cancer (CRC) has been known to complicate Crohn's disease (CD). Several reports in Western population revealed that CRC in CD were characterized by much younger onset and equal distribution of tumors along the entire colon. However, clinicopathologic features of CD-associated CRC in Korean population have not been well documented yet. METHODS: Among 2968 Korean CD patients, 16 patients (0.54%) were found to develop CRC during follow up. We reviewed clinicopathologic features of the 16 CRC patients. RESULTS: The mean age at the time of CRC diagnosis was 39.3 years (range 18-59 years) and 14 of the 16 CRCs (87.5%) occurred in anorectal region. Mucinous adenocarcinoma was strikingly frequent (9/16, 56.3%) and eight cases (8/9) of the mucinous adenocarcinoma cases were located at anorectal area. The other cases consisted of 4 tubular adenocarcinomas, 2 signet ring cell carcinomas and 1 neuroendocrine tumor. Thirteen patients (81.3%) had a history of perianal fistula and 8 of them had a histological association between the CRC and the perianal fistula. CONCLUSIONS: CD-associated CRC was characterized by young age at diagnosis, mucinous histology and association with perianal fistula in Korean patients.
BACKGROUND:Colorectal cancer (CRC) has been known to complicate Crohn's disease (CD). Several reports in Western population revealed that CRC in CD were characterized by much younger onset and equal distribution of tumors along the entire colon. However, clinicopathologic features of CD-associated CRC in Korean population have not been well documented yet. METHODS: Among 2968 Korean CD patients, 16 patients (0.54%) were found to develop CRC during follow up. We reviewed clinicopathologic features of the 16 CRC patients. RESULTS: The mean age at the time of CRC diagnosis was 39.3 years (range 18-59 years) and 14 of the 16 CRCs (87.5%) occurred in anorectal region. Mucinous adenocarcinoma was strikingly frequent (9/16, 56.3%) and eight cases (8/9) of the mucinous adenocarcinoma cases were located at anorectal area. The other cases consisted of 4 tubular adenocarcinomas, 2 signet ring cell carcinomas and 1 neuroendocrine tumor. Thirteen patients (81.3%) had a history of perianal fistula and 8 of them had a histological association between the CRC and the perianal fistula. CONCLUSIONS: CD-associated CRC was characterized by young age at diagnosis, mucinous histology and association with perianal fistula in Korean patients.
Authors: Ana Beatriz Pereira de Souza; Amanda Pereira Lima; Lívia Moreira Genaro; Carla Peres Fingerhut Geiger; Maria de Lourdes Setsuko Ayrizono; Raquel Franco Leal Journal: Int J Surg Case Rep Date: 2022-05-18
Authors: Yoo Na Lee; Jong Lyul Lee; Chang Sik Yu; Jong Beom Kim; Seok-Byung Lim; In Ja Park; Young Sik Yoon; Chan Wook Kim; Suk-Kyun Yang; Byong Duk Ye; Sang Hyoung Park; Jin Cheon Kim Journal: Ann Coloproctol Date: 2021-04-30