| Literature DB >> 2821365 |
K Berne-Fromell1, H Fromell, S Lundkvist, P Lundkvist.
Abstract
We have found that increasing noradrenaline (NA) levels through the use of antidepressants and 1-dopa has effects on the symptoms of MS. On these grounds we wish to present a hypothetical basis of multiple sclerosis and discuss support found in the literature. The hypothesis is that in MS there is a deficiency of NA in the synapses of the nervous system and an interruption of impulse transmission. An interruption of sufficient intensity and duration will lead to axon damage and secondary demyelination.Entities:
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Year: 1987 PMID： 2821365 DOI： 10.1016/0306-9877(87)90062-4
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538