Literature DB >> 2821255

Why is plasma angiotensin-converting enzyme activity elevated in hyperthyroidism?

J E Roulston1, A Gold, M Wright, S W Walker.   

Abstract

The elevation in plasma angiotensin-converting enzyme (ACE) levels observed in patients with hyperthyroidism is unexplained. In this study three hypotheses were investigated. Results from a study using rats treated with thyroid hormones indicated that the increased ACE was not due to increased cleavages of enzyme from lung endothelia. Data from patients with specific tissue damage argue against a nonspecific release of ACE from damaged cells. Data from cultured cell experiments, however, strongly support a direct effect of thyroid hormones upon ACE synthesis and secretion.

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Year:  1987        PMID： 2821255      PMCID： PMC1290952          DOI： 10.1177/014107688708000809

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   5.344


  7 in total

1.  A continuous monitoring spectrophotometric method for the measurement of angiotensin-converting enzyme in human serum.

Authors:  G A Maguire; C P Price
Journal:  Ann Clin Biochem       Date:  1985-03       Impact factor: 2.057

2.  Liver disease in hyperthyroidism.

Authors:  F S Ashkar; R Miller; W M Smoak; A J Gilson
Journal:  South Med J       Date:  1971-04       Impact factor: 0.954

3.  Comparison of serum angiotensin-converting enzyme in Graves' disease, toxic nodular goiter, and other thyroid conditions.

Authors:  H Czernobilsky; W Fiehn; R Ziegler
Journal:  Klin Wochenschr       Date:  1985-06-03

4.  Increased levels of serum angiotensin-converting enzyme activity in hyperthyroidism.

Authors:  H Yotsumoto; Y Imai; N Kuzuya; H Uchimura; F Matsuzaki
Journal:  Ann Intern Med       Date:  1982-03       Impact factor: 25.391

5.  Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.

Authors:  G J Beckett; H A Kellett; S M Gow; A J Hussey; J D Hayes; A D Toft
Journal:  Br Med J (Clin Res Ed)       Date:  1985-08-17

6.  Elevation of serum angiotensin-converting enzyme activity in patients with hyperthyroidism.

Authors:  Y Nakamura; T Takeda; M Ishii; K Nishiyama; M Yamakada; Y Hirata; K Kimura; S Murao
Journal:  J Clin Endocrinol Metab       Date:  1982-11       Impact factor: 5.958

7.  Serum angiotensin-converting enzyme. Alterations in hyperthyroidism, hypothyroidism, and subacute thyroiditis.

Authors:  R C Smallridge; J Rogers; P S Verma
Journal:  JAMA       Date:  1983-11-11       Impact factor: 56.272
  7 in total

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